Asha Therapeutics

[Braganca]

https://www.ashatherapeutics.com/ourscience

Post-viral Illness (Long COVID & ME/CFS)
Mitochondrial Fragmentation is the Commonality
Post-viral illnesses are a set of chronic pathologies with multiple symptomatic profiles including ME/CFS and Long COVID.

Similar to approaches for AD and PD, ASHA-091 intervention in preclinical models of post-viral illness is proving efficacious. Interestingly, ASHA-091 was designed specifically as the first targeted therapy for ME/CFS and post-viral illness and has since proven to have a host of other therapeutic indications including AD and PD as highlighted above.

https://www.ashatherapeutics.com/post/me-cfs

https://twitter.com/user/status/1667632490213670915


https://www.heckmannlab.com/pi-bio

 

[Braganca]

https://twitter.com/user/status/1742136988893937675


https://twitter.com/user/status/1742138239874437383

 

[Mij]

https://www.ashatherapeutics.com/pipeline

 

[JemPD]

oh

You cannot possibly even have a 'mouse model' of ME. PEM is not 'healthy mouse/human having done much more exercise than they're used to'. You cant possibly give a healthy organism 'enough' exhaustion to trigger PEM. PEM is not PEF.

 

[Braganca]

oh

You cannot possibly even have a 'mouse model' of ME. PEM is not 'healthy mouse/human having done much more exercise than they're used to'. You cant possibly give a healthy organism 'enough' exhaustion to trigger PEM. PEM is not PEF.

Yeah the mouse model is unlikely. They did inject the mouse to “induce mitochondrial fragmentation” with two different substances.

Is “DRP1-mediated mitochondrial fragmentation” something anyone has found in ME studies?

Seems like a stretch but happy to see ME as a potential indication, even at a v early, pre-clinical stage.

 

[Wonko]

It'll all be fine.

All they need is a drug to turn people into mice, and one to turn them back to people, maybe even the same people.

Then they can turn someone into a mouse, use the mouse model derived treatment to cure their ME, and then turn them back into a person.

Simple really.

 

[Mij]

Mice can drive now, they'll be just fine as long as they get fed.

 

[Wonko]

I foresee such vehicles experiencing similar issues to those with the Sinclair C5 - absolutely useless for travel on motorways.