C&EN - Common allergy drug makes resistant bacteria vulnerable to antibiotics

MarcNotMark · Jun 14, 2019

Over-the-counter antihistamine loratadine busts bacterial biofilms and helps oxacillin to kill antibiotic-resistant Staphylococcus aureus in the lab

The common antihistamine loratadine—the active ingredient in over-the-counter medications such as Claritin, Alerclear, and Alavert—makes some species of antibiotic-resistant bacteria susceptible to antibiotics in lab experiments (ACS Infect Dis. 2019, DOI: 10.1021/acsinfecdis.9b00096). Loratadine alone also breaks up bacterial biofilms, tight-knit microbial communities that form on implants and catheters and make resistance worse. The results offer a new route to developing drugs for these hard-to-treat infections, the researchers say.
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https://cen.acs.org/pharmaceuticals/antibiotics/Common-allergy-drug-makes-resistant/97/i24

hixxy · Jun 14, 2019

No doubt they'll develop an alternative to loratadine that's no more effective at breaking down biofilms just so they can patent it.

Barry · Jun 15, 2019

Full text.

https://sci-hub.tw/10.1021/acsinfecdis.9b00096

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C&EN - Common allergy drug makes resistant bacteria vulnerable to antibiotics

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