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Case Report: Rapid and partially persistent, improvements of anorexia nervosa and probable ME/CFS upon metreleptin treatment, 2023, Antel et al

Discussion in ''Conditions related to ME/CFS' news and research' started by Sly Saint, Oct 18, 2023.

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  1. Sly Saint

    Sly Saint Senior Member (Voting Rights)

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    Case Report: Rapid and partially persistent, improvements of anorexia nervosa and probable myalgic encephalo-myelitis/chronic fatigue syndrome upon metreleptin treatment during two dosing episodes

    Jochen Antel1* [​IMG]Johannes Hebebrand1 Linda Von Piechowski2 Cordula Kiewert1 Burkhard Stüve3 [​IMG]Gertraud Gradl-Dietsch1

    A comorbidity of anorexia nervosa (AN) and myalgic encephalomyelitis (ME/CSF) is uncommon. A 17-year-old male adolescent with possible onset of ME/CFS after an Epstein Barr Virus infection (EBV) and later onset of AN during a second period of weight loss was twice treated off-label with metreleptin for 15 and 11 days, respectively. As in previous cases, eating disorder specific cognitions and mood improved. Interestingly, fatigue and post-exertional muscle pain (P-EMP) improved, too. We discuss potential mechanisms. Treatment with metreleptin may prove beneficial in AN and in ME/CSF associated with substantial weight loss.

    https://www.frontiersin.org/articles/10.3389/fpsyt.2023.1267495/abstract
     
    Sly Saint, Oct 18, 2023
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  2. Hutan

    Hutan Moderator Staff Member

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    https://go.drugbank.com/drugs/DB09046
    It's interesting, although I imagine correction of a lack of nutrient intake would help many symptoms, including fatigue and probably pain. It's good to hear that there might be a useful treatment for (at least some cases of) what has been labelled anorexia nervosa.
     
    Hutan, Oct 18, 2023
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  3. Hutan

    Hutan Moderator Staff Member

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    There is this relatively recent study of leptin in ME/CFS:
    The Role of Leptin and Inflammatory Related Biomarkers in Individuals with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome, 2022, Assil & Younger

    On the face of it, higher levels of leptin seemed to be more characteristic of ME/CFS than low levels in this sample.

    That makes adding leptin seem less likely to help, but perhaps there is something wrong with the way the natural leptin is working? Or perhaps the group with hypoleptinemia are a subset that leptin supplementation helps?

    I haven't looked closely at either study yet.
     
    Hutan, Oct 18, 2023
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  4. Dolphin

    Dolphin Senior Member (Voting Rights)

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    Dolphin, Nov 9, 2023
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  5. Jaybee00

    Jaybee00 Senior Member (Voting Rights)

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    Metreleptin plus olanzapine.
     
    Jaybee00, Nov 9, 2023
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  6. Dolphin

    Dolphin Senior Member (Voting Rights)

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    Dolphin, Nov 9, 2023
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