Causal evidence that herpes zoster vaccination prevents a proportion of dementia cases, 2023, Markus Eyting

Interesting, thanks!

One possibility is that they independently reduce dementia risk by preventing their respective infections, shingles and RSV. [...] However, the fact that a protective effect is seen within a few months of vaccination (as was observed in our previous study5) argues against this possibility as it seems unlikely that enough infections would be prevented during such a short time frame to explain the magnitude of the protection against dementia.

This seems like it could be important. They thought preventing the shingles infection was helping prevent dementia, but this is pointing to a specific ingredient found in multiple vaccines instead.
 
I think a big problem with these studies is that someone who gets a Shingles or RSV vaccine is not, on average, like a person who does not.

Either, the person who is vaccinated is well enough organised, capable of deciding to do something to maintain their health, making the appointment and getting themselves there. They probably regularly visit the doctor for their other health needs. In which case, they are still thinking well and are regularly seen by a doctor, and so are, at worst, some years off getting diagnosed with dementia.

And/or, the person who is vaccinated lives in a situation where someone is looking after their health needs and getting vaccinations done, and so they are also being closely monitored for signs of dementia. So again, if they had dementia, they would probably have already been diagnosed with it. I imagine in a retirement home, there is more funding for a resident with dementia, so it would be in the retirement home's interests to get the diagnosis fairly quickly.

Contrast that with someone who doesn't get the vaccine. Someone in the first stages of dementia and living on their own will be struggling to hold everything together, and probably won't be thinking about discretionary activities such as getting a vaccine. If the unvaccinated person is living with a spouse or a child who isn't able to arrange for the vaccine or doesn't believe in vaccines, then they probably aren't getting to the doctor often either, and may not be being closely monitored for signs of dementia.


If a person who is vaccinated has any signs of dementia, they probably will have already been diagnosed with it already. So, for them, the chance of being diagnosed in those next 18 months is only the chance of a new onset that moves very swiftly.

Whereas, a person who is not vaccinated may already have quite significant signs of dementia but be undiagnosed. So, for them, the chance of being diagnosed in those next 18 months is the chance of an onset in quite a lot of years prior as well as the next 18 months.
 
I think a big problem with these studies is that someone who gets a Shingles or RSV vaccine is not, on average, like a person who does not.
That's what makes the natural experiment of the first study above useful. A large portion of the people who didn't take the vaccine didn't take it because they weren't allowed to.
Adults born immediately after the 2 September 1933 date-of-birth eligibility cut-off had a 47.2 percentage point higher probability (from 0.01% to 47.2%) of ever receiving the herpes zoster vaccine than those born immediately before this cut-off date.
I think what they did was more sophisticated, but a crude way to test the effect of vaccine on dementia is just seeing how much dementia occurs in the group before September 2 and the group after. The main difference is a different proportion of people who took the vaccine based on whether they were allowed to take the vaccine. Not socioeconomic factors.
 
I don't find it surprising that they are discovering that neurotrophic viruses may put us at a higher risk of developing dementia.

Conclusion

In summary we find an association between symptomatic HSV-1 infection and AD using a large claims database from USA and highlighting antiherpetic therapies as potentially protective for AD. These findings place an even greater emphasis on viewing the prevention of herpesviruses as a public health priority. Further research to determine whether suppression of neurotropic viruses can alter the natural history of AD and ADRD is warranted based on consistent observational studies.
LINK

 
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