Chronic fatigue syndrome post-COVID-19: triple-blind randomised clinical trial of Astragalus root extract 2024 Banihashemi et al

Results
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A total of 137 nurses were identified from the nursing office for initial eligibility screening. We excluded 73 participants because they did not meet the inclusion criteria (51 were not diagnosed with CFS; 22 declined to participate). The remaining 64 participants were then randomly assigned to either the intervention or placebo group.

At the end of the intervention, 4 participants (13.8%) in the Astragalus root extract group (n=29) and 24 (80%) in the control group (n=30) had CFS and at the 1-month follow-up, 5 participants (17.2%) in the Astragalus root extract group and 21 (70 %) in the control group (n=53) had CFS (no missing cases).

Screenshot 2024-06-07 at 8.04.13 AM.png Screenshot 2024-06-07 at 8.04.22 AM.png
 
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At the end of the intervention, 4 participants (13.8%) in the Astragalus root extract group (n=29) and 24 (80%) in the control group (n=30) had CFS and at the 1-month follow-up, 5 participants (17.2%) in the Astragalus root extract group and 21 (70 %) in the control group (n=53) had CFS (no missing cases).

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I mean, it seems pretty significant. Even if it's not actually CFS, which it probably isn't, it looks like this plant might be useful for something. Although, I barely understand any of the statistics on the second chart.
 
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The integrative/functional MD I was seeing 22 years ago recommended adaptogens when it very popular for ME/CFS. I tried a combo adaptogen formula with Astragaus and found it made me feel awful. My brain felt the same as when I took Elavil(amitriptyline).
 
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