Review Chronic inflammatory response syndrome – A review of the evidence of clinical efficacy of treatment, 2024, Dooley

https://journals.lww.com/annals-of-...matory_response_syndrome___a_review.2360.aspx

Dooley, Ming DACMa,*; Vukelic, April DOb; Jim, Lysander MDc. Chronic inflammatory response syndrome – A review of the evidence of clinical efficacy of treatment. Annals of Medicine & Surgery ():10.1097/MS9.0000000000002718, November 8, 2024. | DOI: 10.1097/MS9.0000000000002718

Chronic Inflammatory Response Syndrome is a multi-symptom, multisystem illness acquired
following respiratory exposure to water-damaged buildings.

It is an underrecognized, underdiagnosed dysregulation of the innate immune system that can
affect 25% of the population, therefore representing a silent epidemic.

The only treatment in the published literature documenting clinical efficacy for treatment of
Chronic Inflammatory Response Syndrome is the Shoemaker Protocol.

Myalgic Encephalomyelitis/Chronic Fatigue Syndrome is a common misdiagnosis for Chronic
Inflammatory Response Syndrome but lacks a defined etiology, biomarkers or a treatment
protocol that reverses the underlying conditions.

ABSTRACT

Chronic Inflammatory Response Syndrome (CIRS) is an acquired medical condition
characterized by innate immune dysregulation following respiratory exposure to water-damaged buildings (WDB).

This chronic syndrome involves a range of symptoms that simultaneously
affecting multiple organ systems.

The purpose of this literature review was to search the published literature for successful treatments for Chronic Inflammatory Response Syndrome, an underrecognized, underdiagnosed, multi-symptom multisystem illness that can affect up to 25% of the population, thus representing a silent epidemic.

Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS), a common
misdiagnosis for CIRS, is an entity that has broader awareness within the medical community
despite the absence of a defined etiology, biomarkers or a treatment protocol that reverses the
underlying conditions.

Therefore, the search also included treatments for ME/CFS and Sick Building Syndrome (SBS). Thirteen articles referenced treatment for CIRS, and 22 articles referenced treatment for CFS.

The only treatment with documented clinical efficacy was the Shoemaker Protocol, which was described in 11 of the 13 articles.

This treatment protocol exhibits superior outcomes compared with the treatment protocols for ME/CFS.