https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3551238/ Th above is by Judith Miklossy, highly respected in research involving different types of spirochetal brain infections. It's an interesting read, and can help anyone who is interested in perhaps getting a handle on why chronic Lyme or late stage Lyme, particularly when it involves the brain, can be problematic. Moreover, she does a good job of explaining why comparisons of NeuroBorreliosis to neuro-syphilis can be justified.