Coenzyme Q10 Alleviates Chronic Nucleoside Reverse Transcriptase Inhibitor-Induced Premature Endothelial Senescence, 2019, Dugas et al

Andy · Apr 26, 2019

Thought this looked potentially interesting but the science is way beyond me.

Abstract
Human immunodeficiency virus (HIV)-infected patients undergoing antiretroviral therapy are afforded an increased lifespan but also exhibit an elevated incidence of cardiovascular disease. HIV therapy uses a combination drug approach, and nucleoside reverse transcriptase inhibitors (NRTI) are a backbone of this therapy. Endothelial dysfunction is an initiating event in cardiovascular disease etiology, and in our prior studies, NRTIs induced an endothelial dysfunction that was dependent upon mitochondrial oxidative stress. Moreover, short-term NRTI administration induced a mitophagy-associated endothelial toxicity and increased reactive oxygen species (ROS) production that was rescued by coenzyme Q10 (Q10) or overexpression of a mitochondrial antioxidant enzyme. Thus, our objective was to examine mitochondrial toxicity in endothelial cells after chronic NRTI treatment and evaluate Q10 as a potential adjunct therapy for preventing NRTI-induced mitochondrial toxicity. Human aortic endothelial cells (HAEC) were exposed to chronic NRTI treatment, with or without Q10. ROS production, cell proliferation rate, levels of senescence, and mitochondrial bioenergetic function were determined. Chronic NRTI increased ROS production but decreased population doubling. In addition, NRTI increased the accumulation of β-galactosidase, indicative of an accelerated rate of senescence. Moreover, ATP-linked respiration was diminished. Co-treatment with Q10 delayed the onset of NRTI-induced senescence, decreased ROS production and rescued the cells’ mitochondrial respiration rate. Thus, our findings may suggest antioxidant enrichment approaches for reducing the cardiovascular side effects of NRTI therapy.
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Paywall, https://link.springer.com/article/10.1007/s12012-019-09520-1
Sci Hub, https://sci-hub.se/10.1007/s12012-019-09520-1

ScottTriGuy · Apr 27, 2019

I don't see any mention of dose - I'm already take Q10, but wonder if I should be taking more in light of this study.

I found this section particularly interesting because I am taking the first 2 HIV meds and also taking Rapamune, a mTOR inhibitor.

Tenofovir and emtricitabine promoted mitochondrial stress and premature senescence in human lung and car- diac fibroblasts in an mTORC1-dependent pathway

InitialConditions · Apr 27, 2019

ScottTriGuy said: ↑

I don't see any mention of dose - I'm already take Q10, but wonder if I should be taking more in light of this study.

I found this section particularly interesting because I am taking the first 2 HIV meds and also taking Rapamune, a mTOR inhibitor.

Tenofovir and emtricitabine promoted mitochondrial stress and premature senescence in human lung and car- diac fibroblasts in an mTORC1-dependent pathway
Click to expand...

there's no dosage info because this is an in vitro study. I'm not a biologist, but would assume it's hard to calculate dosages from these sorts of studies.

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Coenzyme Q10 Alleviates Chronic Nucleoside Reverse Transcriptase Inhibitor-Induced Premature Endothelial Senescence, 2019, Dugas et al

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Coenzyme Q10 Alleviates Chronic Nucleoside Reverse Transcriptase Inhibitor-Induced Premature Endothelial Senescence, 2019, Dugas et al

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