Complete remission with histamine blocker in a patient with intractable hyperadrenergic postural orthostatic tachycardia syndrome secondary to PASC

Full Title
Complete remission with histamine blocker in a patient with intractable hyperadrenergic postural orthostatic tachycardia syndrome secondary to long coronavirus disease syndrome, 2024, Gonzalez-Alvarez et al

Abstract

The COVID-19 pandemic caused by the novel severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2), has emerged as a global public health concern and its sequels have barely started to outcrop. A good percentage of patients who suffered from COVID-19 are prone to develop long-COVID or post-COVID condition (PCC), a multisystemic, heterogeneous, chronic disorder.

Patients with PCC may experience diverse manifestations, of which cardiovascular and neurological symptoms are among the most frequently reported. Indeed, dysautonomia presented as orthostatic intolerance has gained room following recent reports linking postural orthostatic tachycardia syndrome (POTS) with PCC. Disturbances in heart rate (HR) and blood pressure (BP) during postural changes are the cornerstones of orthostatic intolerance seen in patients suffering from PCC. A subtype of POTS, hyperadrenergic POTS, has been widely studied because of its association with mast cell activation syndrome (MCAS). Although a causative relationship between PCC, hyperadrenergic POTS, and MCAS remains unrevealed, these syndromes can overlap.

We want to propose here a correlation produced by a close-loop mechanism with positive feedback established after SARS-CoV-2 infection in a previously healthy young patient.

https://journals.lww.com/jhypertens...emission_with_histamine_blocker_in_a.432.aspx

 

Histamine blockers are among the most commonly prescribed things for Long Covid. If they were gamechangers we'd know it by now.

 

I’m surprised loratidine was helpful. I noticed zero effect from it. However, I will say that another (stronger) antihistamine made me go from severe to moderate years ago when even sitting up in bed was impossible and my POTS was extreme.

 

It's dead helpful for cat allergy (for which I now have take it year-round, owing to adopting a kitten and becoming allergic to her three years later ) and hay fever.

Not so much anything else, though.

 

I was watching a really interesting thing about cat allergy this wk. It can be treated by the addition of egg powder to cats food as long as the eggs come from hens that are exposed to cats. There's a new type of Purina cat food coming on the market with this added to it that also helps. There's an explanation of the mechanism here by a consultant allergist in the US : https://vm.tiktok.com/ZGea1ecwK/

And to think your name is Kitty too!!