COVID-19 infection in patients with mast cell disorders including mastocytosis does not impact mast cell activation symptoms, Giannetti et al, 2021

Andy · Feb 26, 2021

No clear abstract is given for this paper, so below is the first paragraph of the main text.

SARS-CoV-2 is a novel coronavirus responsible for the clinical syndrome COVID-19. This virus was initially recognized in December 2019 in Wuhan, China and has since spread leading to a global pandemic. Mast cells (MCs) are tissue resident innate immune cells that play a pathobiologic role in a range of diseases, such as asthma, rhinitis and food allergy and MC activation disorders. MC activation leads to the release of inflammatory mediators, including tryptase and several cytokines such as interleukin (IL)-6. MCs are often active participants in propagation of inflammation during viral infection.(1) Reports of serious COVID-19 infections have identified IL-6, TNF and IL-1β as hallmarks of cytokine storm leading to severe outcomes.(2) MCs are a source of IL-6 and other proinflammatory mediators, leading to the possibility of MCs directly contributing to the severity of SARS-CoV-2 infection. However, studies involving allergic asthma, a disease associated with increased lung MC numbers and activation, have not shown an increased risk for severe outcomes.(3) Thus, the role of MCs in SARS-CoV-2 infection remains unknown.
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Open access, https://www.sciencedirect.com/science/article/pii/S2213219821002038

alktipping · Feb 26, 2021

i think it is way to early to make such assumptions even by a professional in epidemiology. downstream effects of viral infections can take many months to show up .

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COVID-19 infection in patients with mast cell disorders including mastocytosis does not impact mast cell activation symptoms, Giannetti et al, 2021

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COVID-19 infection in patients with mast cell disorders including mastocytosis does not impact mast cell activation symptoms, Giannetti et al, 2021

Andy Committee Member

alktipping Senior Member (Voting Rights)

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