COVID-Specific Long-Term Sequelae in Comparison to Common Viral Respiratory Infections: An Analysis of 17,487 Infected Adult Patients 2022,Baskett

Sly Saint

Sly Saint

Senior Member (Voting Rights)
ABSTRACT
Background
better understanding of long-term health effects after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has become one of the healthcare priorities in the current pandemic. We analyzedlarge and diverse patient cohort to study health effects related to SARS-CoV-2 infection occurring more than one month post-infection.

Methods
We analyzed 17,487 patients who received diagnoses for SARS-CoV-2 infection in a total of 122 healthcare facilities in the United States prior to April, 14,2022. Patients were propensity score matched with patients diagnosed with the common cold, influenza, or viral pneumonia from March 1, 2020, to April 1, 2021. For each outcome, SARS-CoV-2 was compared to a generic Viral Respiratory Infection (VRI) by predicting diagnoses in the period between 30 and 365 days post-infection. Both COVID-19 and VRI patients were propensity score matched with patients with no record of COVID-19 or VRI and the same methodology was applied. Diagnoses where COVID-19 infection was a significant positive predictor in both COVID-19 vs VRI and COVID-19 vs Control comparisons were considered COVID-19-specific effects.

Results
Compared to common VRIs, SARS-CoV-2 was associated with diagnoses palpitations, hair loss, fatigue, chest pain, dyspnea, joint pain, and obesity in the post-infectious period.

Conclusions
We identify that some diagnoses commonly described as “long COVID” do not appear significantly more frequent post-COVID-19 infection compared to other common VRIs. We also identify sequelae which are specifically associated with a prior SARS-CoV-2 infection.

https://academic.oup.com/ofid/advance-article/doi/10.1093/ofid/ofac683/6953331
 
Article about the study

Not all post COVID-19 condition symptoms are specific to the virus
A comparative analysis with common viral infections suggests that many recognised post COVID-19 condition symptoms are not unique to the virus
According to the findings of an analysis by US researchers, only some of the post COVID-19 condition symptoms can be uniquely attributed to infection with the virus when compared to the post-infection symptoms induced by other, common viral infections.

Post COVID-19 condition which is also commonly referred to as long COVID, is defined as the continuation or development of new symptoms 3 months after the initial COVID-19 infection, with these symptoms lasting for at least 2 months with no other explanation. Although there are a number of specific symptoms that have been recognised, the more common ones have included fatigue, cough, chest tightness, breathlessness, palpitations and myalgia. Nevertheless, it is also known that other viral infections can result in lasting symptoms and myalgic encephalomyelitis or post-viral fatigue syndrome is a common disorder, in which patient complain of exhaustion, fatigue, muscle aches and pains, and invariable psychiatric symptoms such as emotional lability, poor memory/concentration, and depression. Thus it is necessary to have a better understanding of the risks associated with the development of specific symptoms to enable a more accurate characterisation of post COVID-19 condition.
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https://hospitalpharmacyeurope.com/...condition-symptoms-are-specific-to-the-virus/
 
That's a fairly middling description of ME. They vaguely reference PEM as "exhaustion", describe cognitive impairment as a psychiatric symptom, then describe depression as an ME symptom. (It's not.) I'll cut them slack because PEM-induced mood swings are real, but it's odd of them to emphasize that.
 
Moved from the Long Covid in the media thread

Researchers looking for long COVID symptoms find only 7

https://www.fiercehealthcare.com/providers/researchers-looking-long-covid-symptoms-find-only-seven
www.fiercehealthcare.com said:
The Centers for Disease Control and Prevention’s tally of 19 possible long COVID symptoms comes with the caveat that it's “not a comprehensive list.”

Yale Medicine counts 22 symptoms, while the Mayo Clinic lists 10. And Great Britain’s National Health Service (NHS) puts the number at 16.

These lists can be made even longer. For instance, the NHS has “high temperature, cough, headaches, sore throat and changes to sense of smell or taste” as one symptom. Mayo lists “difficulty thinking or concentrating, headache, sleep problems, dizziness when you stand, pins-and-needles feeling, loss of smell or taste and depression or anxiety” as one symptom.

A major obstacle to helping patients with long COVID is that currently there are no generally agreed-upon diagnostic or treatment guidelines. Narrowing down exactly what symptoms point to long COVID would be a start, and researchers at the University of Missouri (MU) think they’ve done just that by slimming the field of long COVID symptoms down to just seven: fast-beating heart, hair loss, fatigue, chest pain, shortness of breath, joint pain and obesity.
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The study being discussed is here: https://academic.oup.com/ofid/article/10/1/ofac683/6953331
 
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ahimsa said:
Moved from the Long Covid in the media thread

Researchers looking for long COVID symptoms find only 7

https://www.fiercehealthcare.com/providers/researchers-looking-long-covid-symptoms-find-only-seven


The study being discussed is here: https://academic.oup.com/ofid/article/10/1/ofac683/6953331
Click to expand...

The article headline is very misleading. They were looking in the research specifically for symptoms of Long Covid that are different from symptoms of other post viral conditions, not all the symptoms. The 7 they list are, they found, specific to LC, so may be helpful in diagnosing LC.
 
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