Current research: Shared Underlying Mechanisms of Long-COvid and CFS - A psychoneuroendocrinological and psychoimmunological perspective, 2022, Buntic

Sly Saint · Dec 21, 2022

The Institute for Advanced Studies Luxembourg (IAS) of the University of Luxembourg

The Institute for Advanced Studies Luxembourg (IAS) of the University of Luxembourg held its annual community event on 23 November 2022, on Belval Campus, with interdisciplinarity as a leitmotiv.

Prof. Jens Kreisel, Vice-Rector for Research and nominated Rector of the University, described how the IAS is instrumental to interdisciplinarity at the University, enabling bold and excellent research at the forefront of science and technology: “By building bridges inside the academic community, with international visitors, and the public, the IAS kickstarts new ideas that wouldn’t be funded anywhere elsewhere.”
Ten PhD candidates selected in the 2021 Young Academics programme then showcased their audacious interdisciplinary projects.
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Nina Buntic’s SUMCO project on fatigue in Post-COVID-19 Syndrome and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS), investigates alterations in multiple organ systems and their translation into chronic complaints focusing on interoception, the ability to perceive own bodily states.
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https://wwwfr.uni.lu/layout/set/pri..._young_researchers_at_the_ias_community_event

SUMCO
Shared Underlying Mechanisms of Long-COvid and Chronic Fatigue Syndrome - A psychoneuroendocrinological and psychoimmunological perspective
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Shared Underlying Mechanisms of Long-COvid and Chronic Fatigue Syndrome - A psychoneuroendocrinological and psychoimmunological perspective (SUMCO) – funded by the Institute for Advanced Studies, University of Luxembourg. At least 10 % of patients recovering from Covid-19 develop persistent health consequences such as fatigue, myalgia, or post-exertional malaise. “Long-Covid” is one of the many terms used to describe the occurrence of respiratory, cardiovascular, neurological, and/or gastrointestinal symptoms weeks after the initial infection is resolved. Although some symptoms seem to be unique to Long-Covid (e.g., olfactory & gustatory dysfunction), there is a large symptom overlap with the condition of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). ME/CFS is a complex, multisystem condition affecting 0.89 % of the global population. Different factors have been hypothesized to be involved in the aetiology of ME/CFS, including immune system dysregulation, metabolic alteration, autonomic nervous system (ANS) and limbic system dysfunction, as well as abnormalities in the hypothalamic-pituitary-adrenal (HPA) axis. One popular hypothesis postulates that ME/CFS is a post-infectious fatigue syndrome, as up to 50 % of ME/CFS cases develop after a viral infection (e.g., infection with Epstein-Barr Virus/EBV).

This observation raises the question if Long-Covid and ME/CFS share similarities in underlying pathophysiology, as both conditions seem to occur after viral infections (SARS-CoV-2 & EBV), which trigger dysregulations in the immune system, the ANS, or the HPA axis.

A proper characterization of Long-Covid and ME/CFS by a thorough, interdisciplinary psychological and physiological assessment may help to make a differential diagnostic distinction of the two patient groups.

The aims of the current project are:
(1) To reveal similarities and differences in the pathophysiology of Long-Covid and ME/CFS, as an in-depth understanding of the underlying psychobiology is essential to design adequate prevention in terms of early detection of pathological biomarkers and treatment interventions for Long-Covid syndromes and ME/CFS in terms of a graded exercise therapy. We specifically focus on potential alterations in the immune system, the ANS, and the HPA axis.
(2) We aim to elucidate how these processes translate into severity of fatigue, as the relationship between these alterations and actual symptom distress remains yet unclear. Ultimately, as biological and psychological markers of Long-Covid and ME/CFS can help to monitor the course of symptoms and the potential responsiveness to treatment intervention, we aim
(3) at investigating the effectiveness of a graded exercise therapy on symptom severity and potential improvement in alterations of the immune system, the ANS and the HPA axis.
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https://wwwfr.uni.lu/layout/set/pri...earch_groups/self_regulation_and_health/sumco

"(3) at investigating the effectiveness of a graded exercise therapy on symptom severity and potential improvement in alterations of the immune system, the ANS and the HPA axis."

John Mac · Dec 13, 2022

"A psychoneuroendocrinological and psychoimmunological perspective"

Is there anything they won't attach the word psycho to?

sneyz · Dec 13, 2022

John Mac said: ↑

Is there anything they won't attach the word psycho to?
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Yes, the thoroughly proven null hypothesis: ‘babble’

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Current research: Shared Underlying Mechanisms of Long-COvid and CFS - A psychoneuroendocrinological and psychoimmunological perspective, 2022, Buntic

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Current research: Shared Underlying Mechanisms of Long-COvid and CFS - A psychoneuroendocrinological and psychoimmunological perspective, 2022, Buntic

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sneyz Established Member (Voting Rights)

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