Hoopoe
Senior Member (Voting Rights)
Discriminative value of cardiopulmonary progressive exercise test in mitochondrial myopathy and chronic fatigue syndrome
https://pdfs.semanticscholar.org/8a0e/7ca972959fbf217a50b4c6a3a5f35bf90e74.pdf
I did not read it all but looked for evidence for or against the deconditioning hypothesis. The authors appear to believe that deconditioning cannot explain the results of CFS patients.
https://pdfs.semanticscholar.org/8a0e/7ca972959fbf217a50b4c6a3a5f35bf90e74.pdf
I did not read it all but looked for evidence for or against the deconditioning hypothesis. The authors appear to believe that deconditioning cannot explain the results of CFS patients.
In patients with CFS, it has been hypothesized that physical deconditioning plays a role in fatigue maintenance, since it is possible that the tendency towards hypovolemia, by reduction of venomotor tone and the depletion of salt, collaborates with the reduction in oxygen consumption to affect cardiac output (6). However, in our study, there was no significant difference between control subjects and both groups of patients in oxygen pulse (table 3), so the results found cannot be explained by differences in physical condition. What is the exercise limiting factor in CSF? We observed that the peak HR of the MM and CFS groups is significantly lower than that of controls, without differences in basal HR between them. The HR slope or slope with which heart rate increases is, on the other hand, significantly superior in the CFS group with respect to the two remaining comparative groups. De BP et al. (5) also reported significantly lower peak HR in CFS patients in compare with control subjects. These authors hypothesized that a lower peak HR as a consequence of a slow acceleration in response to exercise. In according to our results, this conclusion may be incorrect because of they did not measured the HR slope. We suggested that an excessive tachycardization in response to exercise provokes early fatigue and it is the exercise limiting factor in CSF.