Do Acute Exercise-Induced Activations of the Kynurenine Pathway Induce Regulatory T-Cells on the Long-Term?.., 2019, Koliamitra et al

Full title: Do Acute Exercise-Induced Activations of the Kynurenine Pathway Induce Regulatory T-Cells on the Long-Term? - A Theoretical Frame Work Supported by Pilot Data.

PubMed link only, https://www.ncbi.nlm.nih.gov/pubmed/31827351

 

Healthy female participants

 

True enough, which is why it's in the "unrelated to ME/CFS" sub-forum. But the question that comes to my mind is "does the same thing happen in ME patients"? Perhaps it doesn't, so perhaps it could be a useful clue for us.

 

If we have IDO2 mutations, then we have nothing to activate.

 

Potentially interesting.

Healthy people (if the hypothesis is correct):

1. exercise activates the kynurenine pathway
2. the kynurenine pathway contributes to Treg differentiation
3. Treg differentiation helps with healthy recovery after exercise
4. healthy person:

PwME (if the metabolic trap hypothesis is correct):

1. exercise doesn't activate the kynurenine pathway correctly because of IDO problems
2. as a result Treg differentiation is compromised
3. as a result there aren't enough of the right Tregs around to ensure healthy recovery after exercise
4. PwME:

 

You see, if science had been explained like this when I was at school, I might have got a bit further with it!