Effects of neck compression on chemoreflex sensitivity and cardiorespiratory hemodynamics in patients with POTS, 2025, Shaun I. Ranada et al

Chemoreflex sensitivity in POTS patients is not altered by neck compression in the supine position. While neck compression reduced resting respiratory rate, it did not change tidal volume or minute ventilation, suggesting that neck compression is unlikely to be effective in reducing hyperventilation in POTS. Reductions in respiratory rate and orthostatic symptoms with neck compression could
be explained by increased vagal outflow due to altered baroreflex function, and not chemoreflex modulation.
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Is hyperventilation a common symptom in POTS?