Trial Report Efficiency of comprehensive rehabilitation of chronic fatigue syndrome due to coronavirus infections COVID-19, 2023, Adambaev

Dolphin · Sep 9, 2023

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https://www.bio-conferences.org/art..._ebwff2023_05039/bioconf_ebwff2023_05039.html

https://www.bio-conferences.org/articles/bioconf/pdf/2023/10/bioconf_ebwff2023_05039.pdf

Efficiency of comprehensive rehabilitation of chronic fatigue syndrome due to coronavirus infections COVID-19

Z.I. Adambaev1* , I.A. Kilichev1 , A.B. Nurzhonov2 , N.Yu. Khudoyberganov1 , and M.R. Niyazmetov1

1 Urgench branch of the Tashkent Medical Academy, Urgench, 220100, Uzbekistan
2 Khorezm Regional Multidisciplinary Medical Center, Urgench, 220100, Uzbekistan

Abstract:

The aim of the study was to study the effectiveness of complex rehabilitation in patients with chronic fatigue syndrome caused by coronovirus infections.

In 120 patients with a confirmed diagnosis of SARS-CoV-2 (COVID-19) aged 20-58 years, post-COVID syndrome or chronic fatigue syndrome was detected, 52 men and 68 women.

Patients had asthenic, cognitive, vegetative manifestations, sleep disorders, smell and taste disorders, anxiety and depression.

Patients received drug therapy: succinic acid preparations, brain metabolic drugs, stimulating antidepressants, sleeping pills - melatonin and B vitamins, among other things, received micropolarization of the head and translingualneurostimulation.

The results of treatment confirmed the effectiveness of the proposed conservative therapy.

The neurological symptoms of post-COVID syndrome - chronic fatigue syndrome (CFS) were studied in 120 patients with a confirmed diagnosis of SARS-CoV-2 (COVID-19), aged 20-58 years. Patients were examined according to the “Questionnaire for the detection of asthenia”, "Mini Mental State Assessment (MMSE)", et.al.

Sleep disorders were studied using the Epworth Sleepiness Scale, anxiety and depression were studied using the “Questionnaire for Determining Anxiety and Depression”.

The patients were divided into 2 groups: the main group (MG) - 69 patients and the control group (CG) - 51 patients.

Patients with MG and CG received drug therapy: succinic acid preparations, brain metabolic drugs, stimulating antidepressants, sleeping pills - melatonin and B vitamins.

And patients with MG, among other things, received micropolarization of the head and translingualneurostimulation.

https://twitter.com/user/status/1700472941597622289

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Hutan · Sep 9, 2023

Abstract said: ↑

And patients with MG, among other things, received micropolarization of the head and translingualneurostimulation.
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In case you were wondering... ('among other things' is not specified)

this paper said:

Micropolarization is the impact on the brain of an ultra-small electric current (up to 1 mA), thereby causing a change in the level of polarization of neuronal and synaptic membranes, which is comparable to natural physiological processes. The mechanism of action of micropolarization is associated with an activating effect on the neurohumoral, axonodentritic components of the brain and spinal cord, on the autonomic nervous system, there is a change in the level of membrane excitability of neurons, the synaptic apparatus, and sensitivity to the perception of ascending afferent flows increases. In other words, a new structure of interneuronal connections is formed in the damaged brain. Excessive, unnecessary connections break up, and instead of them, new, more physiologically effective ones are established [23].

Translingualneurostimulation (TLNS) is a modern rehabilitation method of influencing the central nervous system through the stimulation of tongue receptors. TDNS is carried out using a device whose electrodes are placed directly on the tongue. The device generates electrical impulses, stimulates receptors on the tongue. Impulses are transmitted to the brainstem and then distributed along the ascending, descending and horizontal paths to all parts of the central nervous system. A 20-minute TLNS procedure improves the functioning of various parts of the brain [23].
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Hutan · Sep 9, 2023

It's tempting to make fun of this paper, but these people appear to be claiming to be experts in Long covid and are treating significant numbers of people. Which is, I don't know, sad? They appear to have no doubts about the

The complex rehabilitation of neurological manifestations of post-covid syndrome proposed by us in the form of succinic acid preparations, brain metabolic agents, stimulating antidepressants, hypnotics, B vitamins,
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that constitute their control treatment. I guess they missed the class in Medical Research 101 that noted that 'time is a great healer'.

No mention of dropouts, all outcomes are subjective. the usual recipe for showing that any treatment you like works.

As can be seen from the data obtained, in the MG, who received complex therapy with the inclusion of head micropolarization and translingualneurostimulation, the effectiveness of treatment was better. This confirms that micropolarization and neurostimulation improves the broken neuronal connections in the brain broken by coronovirus infection. Our studies confirm that “the stable effect of brain micropolarization is based on the physiologically adequate action of a small direct current on various areas of the brain and spinal cord with the activation of interstructural and intersystem relationships, supported by self-regulation mechanisms. As a result of micropolarization, a new functional state of the CNS is formed, closer to the norm, with the achievement of the physiological level of dynamic homeostasis disturbed during the pathological process, which provides a new level of implementation of various types of activity” [23].
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