Elevation in histamine and tryptase following exercise in patients with mastocytosis

"We have presented evidence that patients with ISM exhibit a significant and intercorrelated rise in histamine and tryptase following exercise consistent with the conclusion that physical activity can induce mast cell mediator release.

Furthermore, the increase in these mediators in circulation was associated with an exacerbation of mast cell mediator-related symptoms in the ISM cohort. Our current study in patients with ISM coroborates an accumulating body of evidence that suggests that physical exercise can trigger mast cell degranulation."


https://www.sciencedirect.com/sdfe/pdf/download/eid/1-s2.0-S2213219818304392/first-page-pdf

 

Hi Scott, could you please link to the webpage and not the pdf, so we can see date of publication, and the rest of the information ? It also seems that the article is incomplete.

 

It's paywalled, so only the 1st page is visible:

https://www.sciencedirect.com/science/article/abs/pii/S2213219818304392?via=ihub

 

Sci-Hub link:

https://sci-hub.se/https://doi.org/10.1016/j.jaip.2018.07.008