Emerging Roles of Blood-Borne Intact and Respiring Mitochondria as Bidirectional Mediators of Pro- and Anti-Inflammatory Processes, 2020, Esch et al

Andy · Apr 1, 2020

Over the past two decades, a major goal of our research group has been elucidation of the functional roles of several key regulatory molecules in proinflammatory preconditioning involved in the pathophysiology of seemingly diverse human disease states. By necessity, operational definitions of proinflammation must be intrinsically fluid based on recent advances in our understanding of complex regulation of innate and adaptive immune processes. Similar to systemic acute stress, a physiological proinflammatory state appears to be a key autoregulatory mechanism for maintaining optimal immune surveillance against potentially infective microorganisms, viruses, and toxic xenobiotics. Perturbation of normative biochemical and molecular mosaics of ongoing proinflammatory tone, exemplified by altered expression of pro- and anti-inflammatory cytokines and their respective protein complexes, is hypothesized to be a common modality for initiation and full expression of various autoimmune diseases and comorbid syndromes evolving from metabolic and metastatic diseases. The newly reported presence of “free” (extracellular) mitochondria exponentially adds to our hypothesis that in conditions of acute stress, a new source of potential ATP producers may be recruited and present to deal with such an acute process. Furthermore, given this phenomenon, an early surveillance role and a dysfunctional chronic inflammation-prolonging component may also be surmised.
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Open access, https://www.medscimonit.com/abstract/index/idArt/924337/act/2

Forbin · Apr 1, 2020

Found this article from Feb 6th of this year:

Researchers Find Cell-Free Mitochondria Floating in Human Blood

Scientists have detected the organelles outside of cells, apparently functioning perfectly well while drifting around the blood of healthy people, according to findings published recently (January 19) in The FASEB Journal. The researchers who made the discovery propose that the independent mitochondria may be released by cells for signaling purposes, although more work is needed to validate that hypothesis. [bolding mine]
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Well, it's something... and it's in the blood...

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Emerging Roles of Blood-Borne Intact and Respiring Mitochondria as Bidirectional Mediators of Pro- and Anti-Inflammatory Processes, 2020, Esch et al

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Emerging Roles of Blood-Borne Intact and Respiring Mitochondria as Bidirectional Mediators of Pro- and Anti-Inflammatory Processes, 2020, Esch et al

Andy Committee Member

Forbin Senior Member (Voting Rights)

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