Main studies Mitochondrial enzymes discriminate between mitochondrial disorders and chronic fatigue syndrome. Smits B, van den Heuvel L, Knoop H, Küsters B, Janssen A, Borm G, et al. Mitochondrion. 2011 Link to article Metabolic profiling reveals anomalous energy metabolism and oxidative stress pathways in chronic fatigue syndrome patients. Armstrong CW, McGregor NR, Lewis DP, Butt HL, Gooley PR. Metabolomics 2015 Link to article Link to S4ME thread Abnormalities of AMPK activation and glucose uptake in cultured skeletal muscle cells from individuals with chronic fatigue syndrome. Brown AE, Jones DE, Walker M, Newton JL. PLoS ONE. 2015 Link to article Mitochondrial DNA variants correlate with symptoms in myalgic encephalomyelitis/chronic fatigue syndrome. Billing-Ross P, Germain A, Ye K, Keinan A, Gu Z, Hanson MR. Journal of Translational Medicine. 2016 Link to article Metabolic profiling indicates impaired pyruvate dehydrogenase function in myalgic encephalopathy/chronic fatigue syndrome. Fluge OM O.; Bruland O.; Risa K.; Dyrstad S.E.; Alme K.; Rekeland I.G. et al. JCI Insight. 2016 Link to article Link to S4ME thread Elevated Energy Production in Chronic Fatigue Syndrome Patients. Lawson NH, CH.; March D.; Wang X. Journal of Nature and Science. 2016 Link to article Metabolic features of chronic fatigue syndrome. Naviaux RN J.; Li K.; Bright A.T.; Alaynick W.A.; Wang L.; Baxter A. et al. PNAS. 2016 Link to article Metabolic profiling of a myalgic encephalomyelitis/chronic fatigue syndrome discovery cohort reveals disturbances in fatty acid and lipid metabolism†. Germain AR, D.; Levine S.M.; Hanson M.R. Molecular Biosystems. 2017 Link to article Cellular bioenergetics is impaired in patients with chronic fatigue syndrome Cara Tomas , Audrey Brown, Victoria Strassheim, Joanna Elson, Julia Newton, Philip Manning PlosOne 2017 Link to article Link to S4ME thread