Fatigue in Gulf War Illness is associated with tonically high activation in the executive control network - Wylie et al (online 11 December 2018)

Sly Saint · Dec 27, 2018

Fatigue in Gulf War Illness is associated with tonically high activation in the executive control network
Author links open overlay panelWylieG.R.abcGenovaH.bcDobryakovaE.bcDeLucaJ.bcdChiaravallotiN.bcFalvoM.aceCookD.fg

Abstract
Gulf War Illness (GWI) is a chronic, multi-symptom illness that affects approximately 25% of Gulf veterans, with cognitive fatigue as one of its primary symptoms.

Here, we investigated the neural networks associated with cognitive fatigue in GWI by asking 35 veterans with GWI and 25 healthy control subjects to perform a series of fatiguing tasks while in the MRI scanner.

Two types of cognitive fatigue were assessed: state fatigue, which is the fatigue that developed as the tasks were completed, and trait fatigue, or one's propensity to experience fatigue when assessed over several weeks.

Our results showed that the neural networks associated with state and trait fatigue differed. Irrespective of group, the network underlying trait fatigue included areas associated with memory whereas the neural network associated with state fatigue included key areas of a fronto-striatal-thalamic circuit that has been implicated in fatigue in other populations.

As in other investigations of fatigue, the caudate of the basal ganglia was implicated in fatigue.

Furthermore, individuals with GWI showed greater activation than the HC group in frontal and parietal areas for the less difficult task.
This suggests that an inability to modulate brain activation as task demands change may underlie fatigue in GWI.
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https://www.sciencedirect.com/science/article/pii/S2213158218303899

Andy · Dec 27, 2018

Please could you add the year the paper was published to the thread title, thanks.

Jonathan Edwards · Dec 27, 2018

It looks interesting. Different patterns of activity seem to show up in relation to background fatigue status and to current actual fatigue.

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Fatigue in Gulf War Illness is associated with tonically high activation in the executive control network - Wylie et al (online 11 December 2018)

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Fatigue in Gulf War Illness is associated with tonically high activation in the executive control network - Wylie et al (online 11 December 2018)

Sly Saint Senior Member (Voting Rights)

Andy Committee Member

Jonathan Edwards Senior Member (Voting Rights)

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