Fatigue in post-acute sequelae of SARS-CoV2 (PASC) treated with oxygen-ozone autohemotherapy – preliminary results on 100 patients, 2021,Tirelli et al

Andy

Retired committee member
OBJECTIVE: Post-acute sequelae of SARS-CoV2 infection (PASC) are a novel terminology used to describe post-COVID persistent symptoms, mimicking somehow the previously described chronic fatigue syndrome (CFS). In this manuscript, we evaluated a therapeutical approach to address PASC-derived fatigue in a cohort of past-COVID-19 positive patients.

PATIENTS AND METHODS: A number of 100 patients, previously diagnosed as COVID-19 positive subjects and meeting our eligibility criteria, was diagnosed having PASC-related fatigue. They were recruited in the study and treated with oxygen-ozone autohemotherapy (O2-O3-AHT), according to the SIOOT protocol. Patients’ response to O2-O3-AHT and changes in fatigue were measured with the 7-scoring Fatigue Severity Scale (FSS), according to previously published protocols.

RESULTS: Statistics assessed that the effects of O2-O3-AHT on fatigue reduced PASC symptoms by 67%, as a mean, in all the investigated cohort of patients (H = 148.4786 p < 0.0001) (Figure 1). Patients following O2-O3-AHT therapy, quite completely recovered for PASC-associated fatigue, a quote amounting to about two fifths (around 40%) of the whole cohort undergoing ozone treatment and despite most of patients were female subjects, the effect was not influenced by sex distribution (H = 0.7353, p = 0.39117).

CONCLUSIONS: Ozone therapy is able to recover normal functionality and to relief pain and discomfort in the form of PASC-associated fatigue in at least 67% of patients suffering from post-COVID sequelae, aside from sex and age distribution.

Open access, https://www.europeanreview.org/article/26809
 
A very recent paper by Blauersteiner et al9,
associated the CFS-caused fatigue with endothelial
dysfunction and vascular alterations, often
related to disorders in the silent information
regulator 1 and endothelial nitric oxide synthase
(Sirt1/eNOS) axis. In particular, the microRNAs
miR-21, miR-34a, miR-92a, miR-126, and miR-
200c were found to be abundant in CFS patients’
plasma respect to healthy controls9.

Mir-21 is
involved in the immune response10 and mir-34a
is involved in both endothelial and inflammatory
signals, even in COVID-19, as its modified form
mir-34a-5p was found as associated with endothelial
dysfunction (observed in postmortem
cases) in SARS-CoV2 infected individuals11. If
fatigue may depend on endothelial dysfunction,
as observed in CFS12, ozone can exert a fundamental
action on endothelia13.

While the most recent
evidence14 assesses that COVID-19 has an
endothelial and immuno-thrombotic etiopathogenesis,
the role of oxygen-ozone in the regulation
of the endothelial-thrombotic mechanisms
may be particularly intriguing, deserving further
attention by clinical research, particularly for its
action on the nitric oxide (NO) pathway13.

Interestingly,
O2-O3-AHT works perfectly not only in
CFS15 but also in fibromyalgia, where the role of
NO seems to be particularly relevant16,17.
Fundamentally, ozone was successfully used
for chronic fatigue syndrome15, a pathological
disorder with several hallmarks shared with
PASC and involving many organs functions18-
 
I am unclear about whether this practice is even allowed? I am a bit confused. Someone tried to sell this to me once. I never went back for this and other much worse reasons.
 
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