Habitual Coffee, Tea, and Caffeine Consumption, Circulating Metabolites, and the Risk of Cardiometabolic Multimorbidity, 2024, Xujia Lu et al

Abstract
Context
Cardiometabolic multimorbidity (CM) is an increasing public health concern. Previous observational studies have suggested inverse associations between coffee, tea, and caffeine intake and risks of individual cardiometabolic diseases; however, their associations with CM and related biological markers are unknown.

Methods
This prospective study involved 172 315 (for caffeine analysis) and 188 091 (tea and coffee analysis) participants free of any cardiometabolic diseases at baseline from the UK Biobank; 168 metabolites were measured among 88 204 and 96 393 participants. CM was defined as the coexistence of at least 2 of the following conditions: type 2 diabetes, coronary heart disease, and stroke.

Results
Nonlinear inverse associations of coffee, tea, and caffeine intake with the risk of new-onset CM were observed. Compared with nonconsumers or consumers of less than 100 mg caffeine per day, consumers of moderate amount of coffee (3 drinks/d) or caffeine (200-300 mg/d) had the lowest risk for new-onset CM, with respective hazard ratios (95% CIs) of 0.519 (0.417-0.647) and 0.593 (0.499-0.704). Multistate models revealed that moderate coffee or caffeine intake was inversely associated with risks of almost all developmental stages of CM, including transitions from a disease-free state to single cardiometabolic diseases and subsequently to CM. A total of 80 to 97 metabolites, such as lipid components within very low-density lipoprotein, histidine, and glycoprotein acetyls, were identified to be associated with both coffee, tea, or caffeine intake and incident CM.

Conclusion
Habitual coffee or caffeine intake, especially at a moderate level, was associated with a lower risk of new-onset CM and could play important roles in almost all transition phases of CM development. Future studies are warranted to validate the implicated metabolic biomarkers underlying the relation between coffee, tea, and caffeine intake and CM.
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Drink 3 cups of coffee every day for cardiometabolic health !

Here is the summary of this recent paper on benefit of coffee: • Cardiometabolic multimorbidity (CM) is a growing health problem, where people suffer from at least two serious conditions like type 2 diabetes, heart disease, or stroke. Previous studies suggest that drinking coffee, tea, or caffeine might lower the risk of getting these diseases individually, but how they affect CM (having more than one of these diseases together) isn’t fully understood.

In this study, around 172,000-188,000 people without any of these conditions at the start were tracked. They looked at their coffee, tea, and caffeine intake, as well as their blood markers. The results showed that drinking moderate amounts of coffee (about 3 cups per day) or caffeine (200-300 mg/day) was linked to a lower risk of developing CM compared to those who drank none or very little. People who drank these moderate amounts had about 40-50% lower risk of developing CM.

Coffee and caffeine seem to help prevent the development of these diseases in stages: first from healthy to having one condition (like diabetes), and then progressing to more than one condition. The study also found that certain blood components like lipids (fats) and specific proteins were linked to both coffee intake and the risk of CM.

Overall, the study suggests that habitual coffee or caffeine consumption could reduce the risk of developing multiple serious health conditions at the same time.

 

I think the tweeter might be confusing association and causation.

 

They seem to be implying there could be more than correlation as there are ‘implicated metabolic biomarkers’. Although we don’t know what those are as the paper doesn’t seem to be public. Or if those are correlation/causation too or even cause/effect. Maybe they’ve discovered a biomarker which determines if you are a tea or coffee drinker rather than tea and coffee drinking impacting the biomarkers?