High Angiotensin 2 and low ACE2

[neophyte32]

Hello, Are there any of you with MECFS who had COVID (I don't know if it was COVID that triggered MECFS, Lyme disease, or something else...) who have very high levels of angiotensin II (but low blood pressure) and very low levels of ACE2? I had a blood test for protein markers at Amatica (I know they're criticized here, but that's okay) and my results are very high compared to other patients (50 for control and 60 for MECFS/long COVID). Is anyone else in the same situation? I've read studies from 2021 and 2022 that explain that it's related to COVID-19 depleting ACE2 in the long term. This could explain the severity of my MECFS (bedridden for 9 months) and my comorbidities (dysautonomia, POTS...).
Thank you.

P.S.: I'm not asking for interpretation of results; I know that's not allowed here. But I'm posting my blood test results with the percentiles anyway.

 

[boolybooly]

I have no tests and I am not able to interpret yours.

But I can say I have been encountering symptoms lately since a suspected covid variant infection double whammy of Stratus and then Nimbus (on top of ME CFIDS which has caused recurring viruses of various species over 40 years) which I have been trying to interpret using the model you describe in the thread title.

It is sad yet in a way a relief to know someone else is encountering similar problems though I know they are horrid and I am sorry for you and me both. At least we are not alone. It does suggest some people in some situations can encounter ACE2 depletion and RAS related consequences due to longcovid (though RAS theory would predict higher blood pressure, so not that simple). I feel like this really needs to be recognised more openly than it is.

I have done my best to talk about it here... hope it is of interest...

Post in thread 'Post COVID Migraine in a Six Day Cycle'

Sep 12, 2025

Update, whatever bugs or covid variants which are going around are giving me trouble.

Seem to have had two variants in succession. Have had headache problems because some of my treatments had to be suspended.

I looked at longhaulers forum and realised more symptoms are linked to this infection.

The infections disrupted the timings of the inflammatory cycle though many symptoms were in common. When the initial infection symptoms reduced they then began to recur as part of the inflammatory cycle which reasserted itself.

Symptoms as part of the recurring cycle I am now getting are...

• boolybooly

• 

here...

Post in thread '[COVID-19] Pandemic is Associated with a Substantial Rise in Frequency and Severity of Presentation of Youth-Onset Type 2 Diabetes, 2022, Magge et al'

Nov 20, 2025

If there is really is an increased incidence of diabetes following Covid-19, that could be relevant to us.

I haven't read the paper. I wonder though if an increase in diabetes diagnoses might be due to the lockdowns of the early Covid-19 years. If young people are not playing sport and being active as they did before, if they are instead staying at home, eating for something to do and gaining weight, perhaps that would account for an increase in diagnoses. It's interesting that the researchers picked up a change in the sex ratios, with a skew towards boys being more commonly...

• boolybooly

• 

and here...

Thread 'Prevalence of peripheral neuropathy and myopathy in patients post‐COVID‐19 infection, Saif et al.'

Dec 3, 2025

Prevalence of peripheral neuropathy and myopathy in patients post‐COVID‐19 infection - PMC

Severe acute respiratory syndrome (SARS‐CoV‐2), caused by the Coronavirus 2019 (COVID‐19), has become a life‐threatening epidemic, affecting multiple organs, including the nervous system. Recent studies have documented that COVID‐19‐associated ...

pmc.ncbi.nlm.nih.gov

Results​

The prevalence of peripheral neuropathy and myopathy in post‐COVID‐19 patients was 56.3% among all patients. A significant difference was detected among patients of both groups regarding serum creatine phosphokinase level, clinical signs, and electrophysiologic findings of neuropathy and myopathy compared to the control group

This is discussed in the following article and by comparison the usual rate for peripheral neuropathy in older age groups is 8%. There is obviously something going on here...

• boolybooly
• Replies: 2
• Forum: Long Covid research

•