Hospital Records of Pain, Fatigue, or Circulatory Symptoms in Girls Exposed to Human Papillomavirus Vaccination.., 2020, Thomsen et al

Andy · Jan 4, 2020

Full title: Hospital Records of Pain, Fatigue, or Circulatory Symptoms in Girls Exposed to Human Papillomavirus Vaccination: Cohort, Self-controlled Case Series, and Population Time Trend Studies

Human papillomavirus (HPV) vaccination has been associated with subsequent diffuse symptoms in girls, reducing public confidence in the vaccine. We examined if girls have nonspecific outcomes of HPV vaccination, using triangulation from a cohort, self-controlled case series (SCCS), and population time trend study in entire Denmark between 2000-2014.

The study population consisted of 314,017 vaccinated girls and 314,017 age-matched unvaccinated girls (cohort analyses); 11,817 girls with hospital records (SCCS analyses); and 1,465,049 girls and boys (population time trend analyses). Main outcome measures were hospital records of pain, fatigue, or circulatory symptoms. The cohort study revealed no increased risk among HPV vaccine-exposed girls, with incidence rate ratios close to 1.0 for abdominal pain, nonspecific pain, headache, hypotension/syncope, tachycardia (including the postural orthostatic tachycardia syndrome), and malaise/fatigue (including the chronic fatigue syndrome). In the SCCS analyses, we observed no association between HPV vaccination and subsequent symptoms. In time trend analyses, we observed a steady increase in these hospital records in both girls and (HPV-unvaccinated) boys, with no relation to the 2009 HPV vaccine introduction in Denmark’s vaccination program. This study with nationwide coverage showed no evidence of a causal link between HPV vaccination and diffuse autonomic symptoms leading to hospital contact.
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Open access, https://academic.oup.com/aje/advance-article/doi/10.1093/aje/kwz284/5695267

Sarah94 · Jan 4, 2020

They can keep saying that, but it won't change the fact that it happened to people.

Cheshire · Jan 4, 2020

Sarah94 said: ↑

They can keep saying that, but it won't change the fact that it happened to people.
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Of course it happened to people, but at the same rate as people who had not been just vaccinated. There are a lot of things correlated to things happening to people, and we tend to see a process of causation, it's natural.
But only an epidemiology study can indicate if the rate of these things is abnormal or not and if a causal link can be drawn.

Sarah94 · Jan 31, 2020

But another review disagrees.

https://www.ncbi.nlm.nih.gov/m/pubmed/28730271/

https://www.bmj.com/content/366/bmj.l4508.full

"In our critical review, we found that serious adverse event signals were already present in the largest randomised trials of HPV vaccines. These signals were ignored or minimised."

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Hospital Records of Pain, Fatigue, or Circulatory Symptoms in Girls Exposed to Human Papillomavirus Vaccination.., 2020, Thomsen et al

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Hospital Records of Pain, Fatigue, or Circulatory Symptoms in Girls Exposed to Human Papillomavirus Vaccination.., 2020, Thomsen et al

Andy Committee Member

Sarah94 Senior Member (Voting Rights)

Cheshire Moderator Staff Member

Sarah94 Senior Member (Voting Rights)

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