Hydrogen inhalation in rehabilitation program of the medical staff recovered from COVID-19, 2021, Shogenova

https://roscardio.ru/en/archive-ctp/item/991-cardiovascular-therapy-and-prevention-2021-206.html

HYDROGEN INHALATION IN REHABILITATION PROGRAM OF THE MEDICAL STAFF RECOVERED FROM COVID-19

Shogenova L. V.1, Truong Thi Tuet1, Kryukova N. O.1, Yusupkhodzhaeva K. A.1, Pozdnyakova D. D.1, Kim T. G.1,2, Chernyak A. V.3, Kalmanova E. N.1,2, Medvedev O. S.4, Kuropatkina T. A.4, Varfolomeev S. D.5,6,7, Ryabokon A. M. 6,7, Svitich O. A.8, Kostinov M. P.8, Kunio Ibaraki9, Hiroki Maehara10, Chuchalin A. G. 1

1 Pirogov Russian National Research Medical University. Moscow, Russia;2D. D. Pletnev City Clinical Hospital. Moscow, Russia; 3Pulmonology Research Institute, Federal Medical and Biological Agency of Russia. Moscow, Russia; 4Faculty of Fundamental Medicine, Department of Pharmacology, Lomonosov Moscow State University. Moscow, Russia; 5Institute of Physicochemical Foundations of the Functioning of Neural Network and Artificial Intellegence, Lomonosov Moscow State University. Moscow, Russia; 6N. M. Emanuel Institute of Biochemical Physics, Russian Academy of Sciences. Moscow, Russia; 7Faculty of Chemistry, Lomonosov Moscow State University. Moscow, Russia; 8I. I. Mechnikov Scientific Research Institute of Vaccines and Serums. Moscow, Russia; 9Department of Orthopedic Surgery, Graduate School of Medicine, University of the Ryukyus. Okinawa, Japan; 10Hyperbaric Medicine, University of the Ryukyus Hospital. Okinawa, Japan

Luda_Shog@list.ru

Received: 06/07-2021

Revision Received: 23/08-2021

Accepted: 06/09-2021

Active hydrogen inhalation (H(H2O)m) has powerful antioxidant and antiapoptotic effects. In recent years, it has been used in a number of experimental and clinical studies.

Aim. To study the safety and effectiveness of inhalation of the “active form of hydrogen” (AFV;(H(H2O)m)) in the rehabilitation program of coronavirus disease 2019 (COVID-19) survivors during the recovery period.

Material and methods. This randomized controlled parallel prospective study included 60 COVID-19 survivors with post-COVID-19 syndrome (ICD-10: U09.9) during the recovery period, with clinical manifestations of chronic fatigue syndrome (CFS), who received standard therapy in accordance with the management protocol of patients with CFS (ICD-10: G93.3): physiotherapy and medication therapy with drugs containing magnesium, B vitamins and L-carnitine. The patients were divided into 2 groups. The experimental group (n=30) included patients who received hydrogen inhalation for 90 minutes

every day during 10 days (SUISONIA hydrogen inhalation device, Japan). The control group (n=30) consisted of patients who received standard therapy. In both groups, patients were comparable in sex and mean age: in the experimental group — 53 (22; 70) years, in the control group — 51 (25; 70) years. Biological markers of systemic inflammation, oxygen transport, lactate metabolism, intrapulmonary shunting, 6-minute walk test, and vascular endothelial function were determined in all patients on the 1st and 10th days of follow-up.

Results. In the experimental group, a decrease in following parameters was revealed: stiffness index (SI), from 8,8±1,8 to 6,8±1,5 (p<0,0001); ALT, from 24,0±12,7 to 20,22±10,61 U/L (p<0,001); venous blood lactate, from 2,5±0,8 to 1,5±1,0 mmol/L (p<0,001); capillary blood lactate, from 2,9±0,8 to 2,0±0,8 mmol/L (p<0,0001); estimated pulmonary shunt fraction (Qs/Qt, Berggren equation, 1942) from 8,98±5,7 to 5,34±3,2 (p<0,01); white blood cells, from 6,64±1,57 to 5,92±1,32 109/L. In addition, we revealed an increase in the refractive index (RI) from 46,67±13,26% to 63,32±13,44% (p<0,0001), minimum

blood oxygen saturation (SpO2) from 92,25±2,9 to 94,25±1, 56% (p<0,05), direct bilirubin from 2,99±1,41 to 3,39±1,34 μmol/L (p<0,01), partial oxygen tension (PvO2) from 26,9±5,0 to 34,8±5,6 mm Hg (p<0,0001), venous oxygen saturation (SvO2) from 51,8±020,6 to 61,1±018,1% (p<0,05), partial capillary oxygen tension (PcO2) from 48,7±15,4 to 63,8±21,2 mm Hg (p<0,01), capillary oxygen saturation (ScO2) from 82,2±4,2 to 86,2±4,8% (p<0,01), distance in 6 minute walk test from 429±45,0 to 569±60 m.

Conclusion. Inhalation therapy with H(H2O)m in the rehabilitation program of COVID-19 survivors during the recovery period is a safe and highly effective method. Manifestations of silent hypoxemia and endothelial dysfunction decreased, while exercise tolerance increased. As for laboratory tests, a decrease in the white blood cell count, estimated pulmonary shunt fraction and lactate content parameters was revealed.

Keywords: hydrogen, active hydrogen (H(H2O)m), COVID-19, post-COVID-19 syndrome, rehabilitation, lactate, oxygen transport, silent hypoxemia.

Relationships and Activities: none.


For citation: Shogenova L. V., Truong Thi Tuet, Kryukova N. O., Yusupkhodzhaeva K. A., Pozdnyakova D. D., Kim T. G., Chernyak A. V., Kalmanova E. N., Medvedev O. S., Kuropatkina T. A., Varfolomeev S. D., Ryabokon A. M., Svitich O. A., Kostinov M. P., Kunio Ibaraki, Hiroki Maehara, Chuchalin A. G. Hydrogen inhalation in rehabilitation program of the medical staff recovered from COVID-19. Cardiovascular Therapyand Prevention. 2021;20(6):2986. (In Russ.) doi:10.15829/1728-8800-2021-2986