Hypothetical framework for post-COVID 19 condition based on a fibromyalgia pathogenetic model 2023,Martinez-Lavin et al

Abstract


There is a clear clinical overlap between fibromyalgia, myalgic encephalomyelitis, and post-COVID 19 condition. Chronic fatigue, cognitive impairment, and widespread pain characterize these 3 syndromes. A steady line of investigation posits fibromyalgia as stress-evoked sympathetically maintained neuropathic pain syndrome and places dorsal root ganglia dysregulation with the ensuing small fiber neuropathy at the epicenter of fibromyalgia pathogenesis. This article discusses emerging evidence suggesting that similar mechanism may operate in post-COVID 19 condition.


https://link.springer.com/article/10.1007/s10067-023-06743-0

paywalled

 

What do they mean by “stress”, I wonder?
I find myself too stressed to look.

 

Judging from the references, looks to be cellular stress on nerve cells. They look quite good actually.

 

Oh great I was too afraid to look!

 

Agree it seems fine. There is a nod to include psychology in there, but it's mostly about small fibre neuropathy and dorsal root ganglia.