Immune cell which kills most cancers discovered by accident by British scientists in major breakthrough

wastwater · Jan 21, 2020

https://uk.yahoo.com/news/immune-cell-kills-most-cancers-160000581.html

Trish · Jan 21, 2020

This is the paper the article is based on:
Genome-wide CRISPR–Cas9 screening reveals ubiquitous T cell cancer targeting via the monomorphic MHC class I-related protein MR1 by Andrew K Sewell et al. Published yesterday in Nature.

Abstract:
Human leukocyte antigen (HLA)-independent, T cell–mediated targeting of cancer cells would allow immune destruction of malignancies in all individuals.

Here, we use genome-wide CRISPR–Cas9 screening to establish that a T cell receptor (TCR) recognized and killed most human cancer types via the monomorphic MHC class I-related protein, MR1, while remaining inert to noncancerous cells. Unlike mucosal-associated invariant T cells, recognition of target cells by the TCR was independent of bacterial loading. Furthermore, concentration-dependent addition of vitamin B-related metabolite ligands of MR1 reduced TCR recognition of cancer cells, suggesting that recognition occurred via sensing of the cancer metabolome.

An MR1-restricted T cell clone mediated in vivo regression of leukemia and conferred enhanced survival of NSG mice. TCR transfer to T cells of patients enabled killing of autologous and nonautologous melanoma.

These findings offer opportunities for HLA-independent, pan-cancer, pan-population immunotherapies.
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Sci hub:
https://sci-hub.se/https://www.nature.com/articles/s41590-019-0578-8

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Immune cell which kills most cancers discovered by accident by British scientists in major breakthrough

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Immune cell which kills most cancers discovered by accident by British scientists in major breakthrough

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