Preprint Impact of inflammatory response in the acute phase of COVID-19 on predicting objective and subjective post-COVID fatigue, 2024, Péron

https://www.researchsquare.com/article/rs-4374986/v1

Article

Impact of inflammatory response in the acute phase of COVID-19 on predicting objective and subjective post-COVID fatigue

Julie Péron
Anthony Nuber-Champier
Gautier Breville
Philippe Voruz
Isabele Jacot de Alcântara
Patrice Lalive
Gilles Allali
Lamyae Benzakour
Olivia Braillard
Mayssam Nehme
Matteo Coen
Jacques Serratrice
Jean-Luc Reny
Jérôme Pugin
Idris Guessous
Basile Landis
Frédéric Assal
Julie Peron

https://doi.org/10.21203/rs.3.rs-4374986/v1


Abstract:

The biological predictors of objective and subjective fatigue in individuals with post-COVID syndrome remains unclear.

This study aims to ascertain the predictive significance of the immune response measured during the acute phase of SARS-CoV-2 infection on various dimensions of fatigue 6–9 months post-infection.

We examined the association between immune markers obtained from the serum of 54 patients (mean age: 58.69 ± 10.90; female: 31%) and objective and subjective chronic fatigue using general linear mixed models.

Level of IL-1RA, IFNγ and TNFα in plasma and the percentage of monocytes measured in the acute phase of COVID-19 predicted physical and total fatigue.

Moreover, the higher the concentration of TNFα (r=-0.40 ; p = .019) in the acute phase, the greater the lack of awareness of cognitive fatigue 6–9 months post-infection.

These findings shed light on the relationship between acute inflammatory response and the persistence of both objective and subjective fatigue.

Keywords:
SARS-CoV-2
Fatigue
Immunity
COVID-19
Immunology
Long COVID
Inflammation