Dolphin
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https://www.researchsquare.com/article/rs-4374986/v1
Article
Impact of inflammatory response in the acute phase of COVID-19 on predicting objective and subjective post-COVID fatigue
Julie Péron
Anthony Nuber-Champier
Gautier Breville
Philippe Voruz
Isabele Jacot de Alcântara
Patrice Lalive
Gilles Allali
Lamyae Benzakour
Olivia Braillard
Mayssam Nehme
Matteo Coen
Jacques Serratrice
Jean-Luc Reny
Jérôme Pugin
Idris Guessous
Basile Landis
Frédéric Assal
Julie Peron
https://doi.org/10.21203/rs.3.rs-4374986/v1
Abstract:
The biological predictors of objective and subjective fatigue in individuals with post-COVID syndrome remains unclear.
This study aims to ascertain the predictive significance of the immune response measured during the acute phase of SARS-CoV-2 infection on various dimensions of fatigue 6–9 months post-infection.
We examined the association between immune markers obtained from the serum of 54 patients (mean age: 58.69 ± 10.90; female: 31%) and objective and subjective chronic fatigue using general linear mixed models.
Level of IL-1RA, IFNγ and TNFα in plasma and the percentage of monocytes measured in the acute phase of COVID-19 predicted physical and total fatigue.
Moreover, the higher the concentration of TNFα (r=-0.40 ; p = .019) in the acute phase, the greater the lack of awareness of cognitive fatigue 6–9 months post-infection.
These findings shed light on the relationship between acute inflammatory response and the persistence of both objective and subjective fatigue.
Keywords:
SARS-CoV-2
Fatigue
Immunity
COVID-19
Immunology
Long COVID
Inflammation
Article
Impact of inflammatory response in the acute phase of COVID-19 on predicting objective and subjective post-COVID fatigue
Julie Péron
Anthony Nuber-Champier
Gautier Breville
Philippe Voruz
Isabele Jacot de Alcântara
Patrice Lalive
Gilles Allali
Lamyae Benzakour
Olivia Braillard
Mayssam Nehme
Matteo Coen
Jacques Serratrice
Jean-Luc Reny
Jérôme Pugin
Idris Guessous
Basile Landis
Frédéric Assal
Julie Peron
https://doi.org/10.21203/rs.3.rs-4374986/v1
Abstract:
The biological predictors of objective and subjective fatigue in individuals with post-COVID syndrome remains unclear.
This study aims to ascertain the predictive significance of the immune response measured during the acute phase of SARS-CoV-2 infection on various dimensions of fatigue 6–9 months post-infection.
We examined the association between immune markers obtained from the serum of 54 patients (mean age: 58.69 ± 10.90; female: 31%) and objective and subjective chronic fatigue using general linear mixed models.
Level of IL-1RA, IFNγ and TNFα in plasma and the percentage of monocytes measured in the acute phase of COVID-19 predicted physical and total fatigue.
Moreover, the higher the concentration of TNFα (r=-0.40 ; p = .019) in the acute phase, the greater the lack of awareness of cognitive fatigue 6–9 months post-infection.
These findings shed light on the relationship between acute inflammatory response and the persistence of both objective and subjective fatigue.
Keywords:
SARS-CoV-2
Fatigue
Immunity
COVID-19
Immunology
Long COVID
Inflammation
