Impact of pharmacological agents on mitochondrial function: a growing opportunity?, 2019, Stoker et al

Andy · Nov 8, 2019

Present-day drug therapies provide clear beneficial effects as many diseases can be driven into remission and the symptoms of others can be efficiently managed; however, the success of many drugs is limited due to both patient non-compliance and adverse off-target or toxicity-induced effects.

There is emerging evidence that many of these side effects are caused by drug-induced impairment of mitochondrial function and eventual mitochondrial dysfunction. It is imperative to understand how and why drug-induced side effects occur and how mitochondrial function is affected. In an aging population, age-associated drug toxicity is another key area of focus as the majority of patients on medication are older.

Therefore, with an aging population possessing subtle or even more dramatic individual differences in mitochondrial function, there is a growing necessity to identify and understand early on potentially significant drug-associated off-target effects and toxicity issues.

This will not only reduce the number of unwanted side effects linked to mitochondrial toxicity but also identify useful mitochondrial-modulating agents.

Mechanistically, many successful drug classes including diabetic treatments, antibiotics, chemotherapies and antiviral agents have been linked to mitochondrial targeted effects.

This is a growing area, with research to repurpose current medications affecting mitochondrial function being assessed in cancer, the immune system and neurodegenerative disorders including Parkinson's disease.

Here, we review the effects that pharmacological agents have on mitochondrial function and explore the opportunities from these effects as potential disease treatments. Our focus will be on cancer treatment and immune modulation.
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Open access, https://portlandpress.com/biochemso...ct-of-pharmacological-agents-on-mitochondrial

Andy · Nov 9, 2019

Thought this was interesting, a list of drugs, some that are familiar subjects for us, that have negative effects on mitochondrial function.

Amw66 · Nov 9, 2019

One of the reasons Ron Davis advises against anti virals ?

Saz94 · Nov 9, 2019

Amw66 said: ↑

One of the reasons Ron Davis advises against anti virals ?
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Yep

NelliePledge · Nov 10, 2019

In hindsight I reckon it’s possible Fluoxetine could have affected my health. My worst period of flu/colds/laryngitis was the 2-3 years after I’d been on it for a year. I realise that could just be a coincidence tho.

mariovitali · Nov 11, 2019

I would also suggest that every ME patient goes to http://livertox.org to check for any drugs taken before or during ME that result in hepatotoxicity. Mitochondrial function is affected if a drug leads to hepatotoxicity.

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Impact of pharmacological agents on mitochondrial function: a growing opportunity?, 2019, Stoker et al

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Impact of pharmacological agents on mitochondrial function: a growing opportunity?, 2019, Stoker et al

Andy Committee Member

Andy Committee Member

Amw66 Senior Member (Voting Rights)

Saz94 Senior Member (Voting Rights)

NelliePledge Moderator Staff Member

mariovitali Senior Member (Voting Rights)

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