Inadvertant intravenous injections


Dr. John Campbell
1.14M subscribers
Intravenous Injection of Coronavirus Disease 2019 (COVID-19) mRNA Vaccine Can Induce Acute Myopericarditis in Mouse Model https://academic.oup.com/cid/advance-... Background Post-vaccination myocarditis and pericarditis reported after coronavirus mRNA vaccines.

The effect of accidental intravenous injection of this vaccine on the heart is unknown

Methods in mice
Compared difference between i.m. and i.v. injection of vaccine
Clinical manifestations Histopathological changes Tissue mRNA expression Serum levels of cytokines and troponins
With normal saline (NS) control
Results Intravenous SARS-CoV-2 mRNA Vaccine Administration Induced Grossly Visible Pathology in Heart Only IV group developed histopathological changes of myopericarditis Evidenced by cardiomyocyte degeneration Apoptosis Necrosis with adjacent inflammatory cell infiltration Calcific deposits on visceral pericardium But Evidence of coronary artery or other cardiac pathologies was absent Spike antigen (immunostaining) occasionally found in infiltrating immune cells of the heart And in cardiomyocytes and intracardiac vascular endothelial cells The histological changes of myopericarditis after the first IV-priming dose persisted for 2 weeks and were markedly aggravated by a second IM- or IV-booster dose Numerous inflammatory cytokines found in cardiac tissue (interleukin (IL)-1β, interferon (IFN)-β, IL-6, and tumor necrosis factor (TNF)-α) in the IV group but not the IM group compatible with presence of myopericarditis in the IV group Ballooning degeneration of hepatocytes was consistently found in the IV group. All other organs appeared normal. Conclusions In vivo evidence that inadvertent intravenous injection of COVID-19 mRNA vaccines may induce myopericarditis. Brief withdrawal of syringe plunger to exclude blood aspiration may be one possible way to reduce such risk. Both Pfizer/BioNTech and Moderna have clearly stated that their vaccines should only be given via IM route Current CDC and WHO guidelines no longer recommend precautionary measures during IM vaccine administration The CDC Pink Book 2020 and WHO 2015 position paper have recommended against aspiration prior to vaccine injection so as to minimize pain Deltoid to the vastus lateralis? Our study indicates that IV injection of vaccines might partially contribute to this clinical phenotype, thus warranting a reconsideration of the practice of IM injection without aspiration, which carries the risk of inadvertent IV injection. Thrombocytopenia in mice reported in 2006 Blood, (2006) https://ashpublications.org/blood/art... All mice received virus through a single tail vein injection Thrombocytopenia has been consistently reported following the administration of adenoviral gene transfer vectors.
Click to expand...
 
Although I'm not sure about the two Covid vaccine shots I got this year, I've had numerous vaccinations over the past dozen years or so and I have definitely noticed them pulling back on the plunger a little before making the final injection. Whether they do it every time, I can't swear to, but it seems to be "standard operating procedure."

I'm not sure if the issue here is whether there is some instruction not to do the pull back with the Covid vaccine, or whether there isn't a clear cut instruction to always pull back on the plunger. My assumption is that checking to make sure that the the needle is not in a blood vessel is de rigueur, so I'd be surprised if there was an exception for any of the Covid vaccines.

There are intravenous injections, but, so far as I know, they are usually given through an IV line already in place. Whether vaccines would ever be given via an IV line, I don't know. I'd assume that they'd be labeled for intramuscular injection only.
 
Last edited:
It is absolutely de rigueur to aspirate before injecting into any body area. This is so that you know you're intentionally intravascular or extravascular as the case may be. Some agents can cause significant harm if given as an intravenous bolus. This could cause immediate cardiovascular collapse or anaphylaxis for example. Other agents cause local tissue damage with extravasation. It makes no sense to me that aspiration should be avoided to somehow reduce pain at the injection site. Wobbling the needle round just shouldn't be an issue: experienced/skilled practitioners wouldn't do this.

I am shocked to see this as widespread sub-standard practice. It was on evidence again yesterday when President Biden received his booster shot.

ETA: Video of Biden receiving booster shot
 
Last edited:
SNT Gatchaman said:
ETA: Video of Biden receiving booster shot
Click to expand...

There was no way that was a real vaccine shot, and I doubt that anything went into his arm, not even saline or vitamins.

People are supposed to remove any air in the needle, as well as checking that the needle was not in a blood vessel. And injecting something is never done that fast, it would be excruciating.

And I'm just trying to imagine a US nurse or doctor injecting an air bubble into the US president while being videoed. It simply wouldn't happen.
 
Scientific integrity researcher Dr Elisabeth Bik’s comments on the paper behind the claim (bolding mine):

My comments on CID paper claiming that Pfizer vaccination given intravenously (instead of in the muscle) could cause myopericarditis in mice.

The authors appeared to have used a 50 times or 500 times (it's not clear) higher dose than given to humans.

https://pubpeer.com/publications/6DB19C2CE523B3BAEAA8A8A3DCCC7D

How clinically relevant is that?
I mean, it might be good for me to drink 2 liters of water each day, but not 100 or 1000 liters.
I am worried this paper might be used to create fear among folks who are vaccine-hesitant.
​
 
TigerLilea said:
That's how it is being done here where I live, Arnie Pye. They are super fast. It's over and done in seconds.
Click to expand...

The bit that perturbed me the most about the video was the apparent risk of getting air bubbles into the veins or arteries, and that would be true for any injection.
 
You must log in or register to reply here.
Back
Top Bottom