Mentions RA @Jonathan Edwards https://www.nytimes.com/2024/09/16/...e_code=1.LE4.-lTA.n840jCDUEDEA&smid=url-share
She doesn't understand. Not sure why this 'essay' is on this site? It is a word salad of stuff that an AI would be likely to generate looking at the literature without understanding what inflammation is.
Inflammation is when tissues go red or swell (redness as in flames) in response to signal molecules like histamine, prostaglandins, bradykinin and cytokines like TNF and IL-6. The central event is dilatation (redness) and increase in permeability (swelling) of the small blood vessels. Initially the swelling is fluid. Later it is also cells. Inflammation occurs in rheumatoid arthritis and pneumonia and also in multiple sclerosis, where you cannot see redness of the brain but the changes in permeability are there and the tissue fills with cells. In recent times medics and biomedical scientists have increasingly confused inflammation itself with the presence of the signals that may trigger inflammation locally. So if they find TNF in the circulation they call it inflammation. If they find signs of IL-6 production - usually in terms of raised C-reactive protein - they say there is inflammation. But this completely ignores the fact that these signals act locally and across specific compartments. TNF in a tissue will activate blood vessel cells to become stickier and bring in cells. But TNF in the circulation doesn't, because the signal isn't calling cells into any particular place. Complement even works backwards in the circulation . It is pro-inflammatory if activate din tissue and anti-inflammatory if activated in blood. And inflammation is not some underlying troll-like process hiding under a bridge 'driving' anything. It is the end result of various other processes. The causal story has been turned back to front. It is a reflection of modern buzz-word science. Unless one talks in terms of the individual processes in a chain of events you end up with gibberish like this essay.
Indeed, but it is widening of tubes full of redness (blood) so is the reason for the redness of the tissue.
Infections Antibody-antigen interaction in tissues in autoimmunity and allergy Trauma Ischaemia from vascular disease or diabetes Thrombosis in phlebitis T cell responses in graft versus host disease and in spondarthropathies Invasion of tissue by cancer Foreign bodies Deposition of crystals of monosodium crate or calcium pyrophosphate Genetic defects in phagocyte proteins in inherited fevers ... There are lots of processes that set off the inflammatory reaction.
