Insane in the Membrane: Glial Extracellular Vesicles Transmit Polyomaviruses, 2019, Santiana and Altan-Bonnet

Andy · May 30, 2019

Posted almost as much for the title as the contents..

ABSTRACT
Extracellular vesicles (EVs) are major vehicles for transporting viruses en bloc among hosts. While RNA viruses make up the great majority of transmission by EVs, in a recent article in mBio (mBio 10:e00379-19, 2019, https://mbio.asm.org/content/10/2/e00379-19.long), Morris-Love and colleagues revealed that a double-stranded DNA (dsDNA) virus, JC polyomavirus (JCPyV), a major cause of progressive multifocal leukoencephalopathy (PML), can be released from and transmitted to other glia in EVs.

This mode of transmission appears to be highly infectious, independent of the free virus attachment and entry receptors LSTc and 5-HT2, and protected from neutralizing antibodies. This novel form of JCPyV transmission may potentially explain its dissemination into the central nervous system (CNS) and its increased virulence.
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Open access, https://mbio.asm.org/content/10/3/e01024-19

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Insane in the Membrane: Glial Extracellular Vesicles Transmit Polyomaviruses, 2019, Santiana and Altan-Bonnet

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Insane in the Membrane: Glial Extracellular Vesicles Transmit Polyomaviruses, 2019, Santiana and Altan-Bonnet

Andy Committee Member

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