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Is hereditary alpha-tryptasemia behind MCAS/dysautonomia/hEDS cases?

Discussion in 'Hypersensitivity and Intolerance Reactions' started by Hoopoe, Aug 4, 2019.

  1. Hoopoe

    Hoopoe Senior Member (Voting Rights)

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    The NIH has a page on this:

    https://www.niaid.nih.gov/research/hereditary-alpha-tryptasemia-faq

    (I edited this so that it quotes the NIH directly)
     
    Last edited: Aug 4, 2019
    Hoopoe, Aug 4, 2019
    #1
    hinterland, Binkie4, andypants and 8 others like this.
  2. Hoopoe

    Hoopoe Senior Member (Voting Rights)

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    Hoopoe, Aug 4, 2019
    #2
    Kitty likes this.
  3. Binkie4

    Binkie4 Senior Member (Voting Rights)

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    Binkie4, Aug 24, 2019
    #3
  4. Jonathan Edwards

    Jonathan Edwards Senior Member (Voting Rights)

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    Location:
    London, UK
    As far as I can see this page tells us nothing useful. Almost every sentence includes 'may' this or 'may' that. A number of statements suggest that whoever is writing it does not really understand what is science and what is hearsay. I suspect that as in the UK government bodies like NIH are increasingly allowing all sorts of doubtful stuff to be put up on webpages. The scramble to be patient friendly has led to nobody trying to tease out the facts from the garbage.

    The page seems to say that it is not known whether the tryptase level has anything to do with mast cells. I don't see what it would have to do with dysautonomia. And I don't think there is any evidence for a genetic link to hEDS.
     
    Jonathan Edwards, Aug 24, 2019
    #4
    obeat and TrixieStix like this.

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