Jekyll and Hyde: the transformation of HLA-B27, 2000, Edwards, J CW et al, Immunology Today

From @MSEsperanza:


Jekyll and Hyde: the transformation of HLA-B27

Abstract:

HLA-B27 can adopt a homodimeric form. In spondyloarthritis, such aberrant expression of B27 may override a tissue-specific inhibition of major histocompatibility complex (MHC) class I-dependent events, leading to inflammation and fibrosis.

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Citation: Jonathan C.W Edwards, Paul Bowness, James R Archer (2000), Jekyll and Hyde: the transformation of HLA-B27,
Immunology Today, Vol 21, Issue 6, https://doi.org/10.1016/S0167-5699(00)01625-X.

https://www.sciencedirect.com/science/article/pii/S016756990001625X

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From @MSEsperanza:

@Jonathan Edwards referred to that paper a couple of times and most recently I think in relation to his The 'writing on the wall' hypothesis so thought a thread of its own could be worthwhile.

References on S4ME see here:

https://www.s4me.info/search/31562856/?q=Bowness&o=date