Ketogenic Diets Alter the Gut Microbiome Resulting in Decreased Intestinal Th17 Cells, 2020, Ang et al

Andy · May 25, 2020

In mice.

Highlights

Ketogenic diets (KDs) alter the gut microbiota in a manner distinct from high-fat diets

Gut microbial shifts on KDs are driven in part through host production of ketone bodies

β-hydroxybutyrate selectively inhibits bifidobacterial growth

The KD-associated gut microbiota reduces levels of intestinal Th17 cells

Summary
Very low-carbohydrate, high-fat ketogenic diets (KDs) induce a pronounced shift in metabolic fuel utilization that elevates circulating ketone bodies; however, the consequences of these compounds for host-microbiome interactions remain unknown. Here, we show that KDs alter the human and mouse gut microbiota in a manner distinct from high-fat diets (HFDs). Metagenomic and metabolomic analyses of stool samples from an 8-week inpatient study revealed marked shifts in gut microbial community structure and function during the KD. Gradient diet experiments in mice confirmed the unique impact of KDs relative to HFDs with a reproducible depletion of bifidobacteria.

In vitro and in vivo experiments showed that ketone bodies selectively inhibited bifidobacterial growth. Finally, mono-colonizations and human microbiome transplantations into germ-free mice revealed that the KD-associated gut microbiota reduces the levels of intestinal pro-inflammatory Th17 cells. Together, these results highlight the importance of trans-kingdom chemical dialogs for mediating the host response to dietary interventions.
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Paywall, https://www.cell.com/cell/pdf/S0092-8674(20)30490-6.pdf
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Midnattsol · May 25, 2020

Cool I have to read it all before I'm gjetting too excited though, there could be other difference between their version of ketogenic and high-fat-diet that could explain this.

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Ketogenic Diets Alter the Gut Microbiome Resulting in Decreased Intestinal Th17 Cells, 2020, Ang et al

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Ketogenic Diets Alter the Gut Microbiome Resulting in Decreased Intestinal Th17 Cells, 2020, Ang et al

Andy Committee Member

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