Andy
Retired committee member
SARS-COV- 2 is now recognized to be responsible not only for a lung condition but a multi-organ syndrome (Ramakrishnan et al., 2021).
After the initial acute infection, like many other viral disorders, a multitude of long-lasting symptoms have been described. Although widely discussed in social media the evidence around this new syndrome is scarce. A provisional definition would be persistent symptoms and potential sequelae beyond four weeks from onset, of which the main features are breathlessness, cognitive impairment, fatigue, anxiety and depression (Ramakrishnan et al., 2021). The often mentioned “brain fog” is characterised by difficulties with concentration, memory and executive function (Carfì et al., 2020). Post-viral syndrome is more common in depressed patients but can occur after a number of viral infections, for example EBV, HSV and HTLV (Burrell et al., 2017).
Reports of the prevalence of ongoing symptoms after COVID infection range from 32.6% to 87% of hospitalised patients. (Nalbandian et al., 2021; Bell et al., 2021).
In a non-hospitalised cohort, 37% report fatigue and 30% cognitive impairment (Chopra et al., 2021). In Wuhan, China, 76% of infected patients were still troubled with at least one symptom after 6 months after discharge (Huang et al., 2021). A Melbourne study found persistent symptoms in 34% even after 45 weeks (COVID, COVID, 2021). These raw data may just reflect local conditions and are unadjusted for standard variables such as age, gender, ethnicity, employment, social deprivation, medications that are sedating, and co-morbidities such as diabetes, obesity and vascular disease.
Open access, https://www.msard-journal.com/article/S2211-0348(21)00535-6/fulltext#
After the initial acute infection, like many other viral disorders, a multitude of long-lasting symptoms have been described. Although widely discussed in social media the evidence around this new syndrome is scarce. A provisional definition would be persistent symptoms and potential sequelae beyond four weeks from onset, of which the main features are breathlessness, cognitive impairment, fatigue, anxiety and depression (Ramakrishnan et al., 2021). The often mentioned “brain fog” is characterised by difficulties with concentration, memory and executive function (Carfì et al., 2020). Post-viral syndrome is more common in depressed patients but can occur after a number of viral infections, for example EBV, HSV and HTLV (Burrell et al., 2017).
Reports of the prevalence of ongoing symptoms after COVID infection range from 32.6% to 87% of hospitalised patients. (Nalbandian et al., 2021; Bell et al., 2021).
In a non-hospitalised cohort, 37% report fatigue and 30% cognitive impairment (Chopra et al., 2021). In Wuhan, China, 76% of infected patients were still troubled with at least one symptom after 6 months after discharge (Huang et al., 2021). A Melbourne study found persistent symptoms in 34% even after 45 weeks (COVID, COVID, 2021). These raw data may just reflect local conditions and are unadjusted for standard variables such as age, gender, ethnicity, employment, social deprivation, medications that are sedating, and co-morbidities such as diabetes, obesity and vascular disease.
Open access, https://www.msard-journal.com/article/S2211-0348(21)00535-6/fulltext#