Low blood pyruvate levels and their association with chronic fatigue syndrome and BMI, 2024, Râtea

[Dolphin]

https://ibn.idsi.md/sites/default/files/imag_file/358-364_5.pdf

CZU: 616.15:616.009.17
DOI: https://doi.org/10.52692/cfzl2024.38

LOW BLOOD PYRUVATE LEVELS AND THEIR ASSOCIATION WITH CHRONIC FATIGUE SYNDROME AND BMI

Râtea Camelia
Moldova State University, Doctoral School in Natural Sciences, Chisinau, Republic of Moldova, nirasteancamelia@yahoo.com Mitogenix innovations and cil food Romania

Abstract.

The aim of this study was to investigate the relationship between low blood pyruvate levels, Chronic Fatigue Syndrome (CFS) and body mass index.

We conducted a small study involving 31 patients diagnosed with CFS and overweight or obese, distribution between male and female are 28 women and 3 men.

Blood samples were collected from all participants at Alfalab Chisinau, Pyruvate in plasma (pyruvic acid) using the NaF blood the analysis was performed at MDI Limbach Berlin GmbH MVZ Labor Limbach Berlin, Germany, normal reference range of 24-95 µmol/l.

Other data were collected during nutritional consultations, at NUTHEIA EDUCATION SRL – Nutrition and Dietetics Center, Chisinau, such as the levels of BMI were recorded using Bioimpedance Scale.

Other relevant measures, such as signs and symptoms of eating and digestive disorders reported by the patient, were also recorded during the nutritional assesment.

The study found that patients with CFS had lower levels of blood pyruvate furthermore, there was a correlation between blood pyruvate levels and Body mass index.

These findings suggest that low blood pyruvate levels are associated with CFS and may contribute to the pathophysiology of the syndrome.

This study highlights the potential of blood pyruvate levels as a biomarker for diagnosing CFS and guiding nutritional treatment strategies in overweight and obese people.

Key words. Pyruvate, Body mass index, chronic fatigue syndrome (CFS), poor nutrition, health.

 

[SNT Gatchaman]

patients evaluated at NUTHEIA EDUCATION SRL in Chisinau, based on inclusion criteria such as a diagnosis of chronic fatigue syndrome, a BMI higher than 24.9 kg/m², and the presence of eating and digestive disorders, including bloating and constipation symptoms.

 

[Hutan]

The study found that patients with CFS had lower levels of blood pyruvate furthermore, there was a correlation between blood pyruvate levels and Body mass index.

Lower levels of pyruvate than what? Healthy controls of the same age? Healthy controls of the same age and BMI?

 

[forestglip]

Lower levels of pyruvate than what? Healthy controls of the same age? Healthy controls of the same age and BMI?

All 31 participants in this study with chronic fatigue syndrome in the dataset have pyruvate values outside the normal range of 24-95 micromol/L.

Looks to be comparing to a reference range.

Marshfield Labs says 30-100 micromol/L, so theirs seems right.

The highest in this study was 17.16 micromol/L. The lowest was 3.58.

Edit: Oops, removed Mayo Clinic Labs range. Pyruvic acid is not the same thing as pyruvate.

 

[forestglip]

I think this is unlikely to be a real result because of how extreme the results are, but looking for related literature just in case:

Post-Exertional Malaise Is Associated with Hypermetabolism, Hypoacetylation and Purine Metabolism Deregulation in ME/CFS Cases, 2019, McGregor, Armstrong et al

The urine percentage data showed falls in urea, pyruvate and acetate with both the 7-day severity and 12-month frequency scores.

Elevated Xenobiotics, Lactate and Pyruvate in C.F.S. Patients, 1989, Buist
5 of 6 patients had very high levels, over 300 micromol/L.


A map of metabolic phenotypes in patients with myalgic encephalomyelitis/chronic fatigue syndrome, 2021, Hoel et al

[ME/CFS clustered into two groups using machine learning]

Minor effects were found for pyruvate [non-significant decrease in ME-M1 subset]. There was a significant increase in serum pyruvate in the ME-M2 subset