mGluR5 mediates post-radiotherapy fatigue development in cancer patients (2018) Saligan et al.

mGluR5 mediates post-radiotherapy fatigue development in cancer patients

https://www.nature.com/articles/s41398-018-0161-3

In essence, a genetic vulnerability primes the immune system to an inflammatory reponse to radiotherapy in those who develop long term fatigue.

Interestingly these individuals report no fatigue issues prior to radiotherapy suggesting a 'two-hit' scenario.

 

Does this tie in with the Moreau twin study highlighted on another thread by @wigglethemouse which found gluatamate genetics differing from controls?
https://www.s4me.info/threads/machine-learning-assisted-research-on-me-cfs.5015/page-7

 

Possibly. I'm relating it to this : https://www.s4me.info/threads/a-study-i-want-someone-to-do.11143/page-2#post-199831