Mitochondria and Microbiota dysfunction in COVID-19 pathogenesis, 2020, Saleh et al

Andy · Jun 24, 2020

The COVID-19 pandemic caused by the coronavirus (SARS-CoV-2) has taken the world by surprise into a major crisis of overwhelming morbidity and mortality. This highly infectious disease is associated with respiratory failure unusual in other coronavirus infections. Mounting evidence link the accelerated progression of the disease in COVID-19 patients to the hyper-inflammatory state termed as the “cytokine storm” involving major systemic perturbations. These include iron dysregulation manifested as hyperferritinemia associated with disease severity. Iron dysregulation induces reactive oxygen species (ROS) production and promotes oxidative stress. The mitochondria are the hub of cellular oxidative homeostasis. In addition, the mitochondria may circulate “cell-free” in non-nucleated platelets, in extracellular vesicles and mitochondrial DNA is found in the extracellular space. The heightened inflammatory/oxidative state may lead to mitochondrial dysfunction leading to platelet damage and apoptosis. The interaction of dysfunctional platelets with coagulation cascades aggravates clotting events and thrombus formation. Furthermore, mitochondrial oxidative stress may contribute to microbiota dysbiosis, altering coagulation pathways and fueling the inflammatory/oxidative response leading to the vicious cycle of events.

Here, we discuss various cellular and systemic incidents caused by SARS-CoV-2 that may critically impact intra and extracellular mitochondrial function, and contribute to the progression and severity of the disease. It is crucial to understand how these key modulators impact COVID-19 pathogenesis in the quest to identify novel therapeutic targets that may reduce fatal outcomes of the disease.
Click to expand...

Open access, https://www.sciencedirect.com/science/article/pii/S1567724920301380

Mithriel · Jun 24, 2020

I am sure I remember some research where they gave ME patients blood thinners. Though it might have been a theory or I could have dreamt it

DokaGirl · Jun 24, 2020

Yes, @Mithriel, there has been research on ME and blood thinners. Here is the MEpedia info on that: https://www.me-pedia.org/wiki/Heparin

Mithriel · Jun 24, 2020

Thank you.

DokaGirl · Jun 24, 2020

@Mithriel, you're welcome.

Log in or Sign up

Mitochondria and Microbiota dysfunction in COVID-19 pathogenesis, 2020, Saleh et al

Andy Committee Member

Mithriel Senior Member (Voting Rights)

DokaGirl Senior Member (Voting Rights)

Mithriel Senior Member (Voting Rights)

DokaGirl Senior Member (Voting Rights)

Share This Page

Log in or Sign up

Mitochondria and Microbiota dysfunction in COVID-19 pathogenesis, 2020, Saleh et al

Andy Committee Member

Mithriel Senior Member (Voting Rights)

DokaGirl Senior Member (Voting Rights)

Mithriel Senior Member (Voting Rights)

DokaGirl Senior Member (Voting Rights)

Share This Page

Useful Searches