Mitochondrial targets of metformin—Are they physiologically relevant?, 2019, Pecinova et al

Andy · Jul 26, 2019

Posting for general interest as some patients report taking metformin.

Abstract
Metformin is the most widely prescribed treatment of hyperglycemia and type II diabetes since 1970s. During the last 15 years, its popularity increased due to epidemiological evidence, that metformin administration reduces incidence of cancer. However, despite the ongoing effort of many researchers, the molecular mechanisms underlying antihyperglycemic or antineoplastic action of metformin remain elusive. Most frequently, metformin is associated with modulation of mitochondrial metabolism leading to lowering of blood glucose or activation of antitumorigenic pathways. Here we review the reported effects of metformin on mitochondrial metabolism and their potential relevance as effective molecular targets with beneficial therapeutic outcome.
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Paywall, https://iubmb.onlinelibrary.wiley.com/doi/abs/10.1002/biof.1548
Sci hub, https://sci-hub.se/10.1002/biof.1548

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Mitochondrial targets of metformin—Are they physiologically relevant?, 2019, Pecinova et al

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Mitochondrial targets of metformin—Are they physiologically relevant?, 2019, Pecinova et al

Andy Committee Member

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