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Review Multiorgan sequelae following non-COVID-19 respiratory infections: a review, 2025, Weckler et al.

Discussion in 'Other health news and research' started by SNT Gatchaman, Apr 5, 2025.

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  1. SNT Gatchaman

    SNT Gatchaman Senior Member (Voting Rights) Staff Member

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    Multiorgan sequelae following non-COVID-19 respiratory infections: a review
    Weckler, Barbara Christine; Kutzinski, Max; Vogelmeier, Claus Franz; Schmeck, Bernd

    BACKGROUND
    While numerous studies have documented severe and long-term health impacts of COVID-19 infections on various organs, the prolonged multisystemic implications of other acute respiratory infections (ARIs) are poorly understood. This review therefore analyzed currently available studies about these sequelae of ARIs excluding COVID-19.

    MAIN BODY
    Multiple pathogens causing ARIs are associated with significant long-lasting impairments across various organ systems. Cardiovascular events occur in 10–35% of patients following ARIs, with an elevated risk persisting for 10 years. The stroke incidence ratio increases significantly after ARIs up to 12.3. Pulmonary sequelae are common, including abnormal lung function in 54%, parenchymal opacification in 51%, lung fibrosis in 33–62%, asthma in 30%, and bronchiectasis in 24% of patients. The risk of developing dementia is increased 2.2-fold. Posttraumatic stress disorder, depression, anxiety, and chronic fatigue occur in 15–43%, 15–36%, 14–62%, and 27–75% of patients, respectively. 28-day mortality from CAP with (versus no) additional cardiovascular event is increased to 36% (versus 10%). Long-term mortality from CAP (versus no CAP) remains elevated for years post-infection, with a 1-year, 5-year, and 7-year mortality rate of 17% (versus 4%), 43% (versus 19%), and 53% (versus 24%), respectively. Patients´ quality of life is significantly reduced, with 17% receiving invalidity pensions and 22% retiring within 4 years of severe ARIs.

    CONCLUSION
    Non-COVID-19 ARIs are associated with clinically relevant, frequent, and long-term sequelae involving multiple organ systems. Further prospective studies are needed.

    Link | PDF (Infection) [Open Access]
     
    SNT Gatchaman, Apr 5, 2025
    #1
    Peter Trewhitt and forestglip like this.
  2. SNT Gatchaman

    SNT Gatchaman Senior Member (Voting Rights) Staff Member

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    Under "Psychiatric, cognitive, and fatigue-related complications" —

    Concluding —

     
    SNT Gatchaman, Apr 5, 2025
    #2
    Peter Trewhitt and forestglip like this.
  3. rvallee

    rvallee Senior Member (Voting Rights)

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    Thing is, it's actually likely that almost all disease-causing pathogens do that, with some to a small degree, others more significant. If that were the case, there is simply no way we could actually validate this, for technical, economic, cultural, and basic human reasons. Especially since medicine has a huge blind spot where it very badly does not want this to be true, will desperately look for any reason, including inventing weird nonsensical pseudoscience to explain it away.

    Especially when you know how the process works, what pathogens do when they invade, and how the immune system deals with it: with extreme prejudice. It always leave damage behind, it basically can't not leave a mark. It's like a shootout between armies who also have grenade launchers and flame-throwing tanks, at the best of times.

    It's possible that most of that damage is eventually repaired, but it's not realistic to think that it's repaired perfectly. It's very likely that this is the norm, that it always happens, but that most of it is small enough that we barely notice each injury, but that the sum of it all is actually the cause of most health problems that aren't related to aging, physical injury or other disease-causing things like pollution and chemicals we are exposed to, some of which is natural (toxins, venoms, and so on).

    But we truly have no way to know. Not with our current level of science and technology, anyway. Not with such an extreme level of motivated unreasoning leading the medical profession to twist itself into multidimensional knots about how it's the psychological reaction that has caused almost all of this. This is simply not normal or rational. And science just doesn't work in those conditions.
     
    rvallee, Apr 7, 2025
    #3

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