Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): An Overview, 2021, Deumer et al

Abstract
Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a chronic systemic disease that manifests via various symptoms such as chronic fatigue, post-exertional malaise, and cognitive impairment described as “brain fog”. These symptoms often prevent patients from keeping up their pre-disease onset lifestyle, as extended periods of physical or mental activity become almost impossible. However, the disease presents heterogeneously with varying severity across patients. Therefore, consensus criteria have been designed to provide a diagnosis based on symptoms. To date, no biomarker-based tests or diagnoses are available, since the molecular changes observed also largely differ from patient to patient. In this review, we discuss the infectious, genetic, and hormonal components that may be involved in CFS pathogenesis, we scrutinize the role of gut microbiota in disease progression, we highlight the potential of non-coding RNA (ncRNA) for the development of diagnostic tools and briefly mention the possibility of SARS-CoV-2 infection causing CFS.

https://www.mdpi.com/2077-0383/10/20/4786

 

Is this a new research group? Don't recognize the names.

Does anyone know them?

 

One of the lead authors, Angelica Varesi, and some of the other authors are based at the University of Pavia in Italy. They may be colleagues of Prof Enrica Capelli, who was part of EUROMENE.

 

no, I've not come across them before. most of them seem to be from Italy.

But I think someone needs to give them an update

"Oftentimes, doctors advise CFS patients to rest physically. However, it is important to point out that patients, especially those with a depressive disorder and no contraindications for physical stress, should be recommended to undergo structured and supervised physical training, as exercise therapy has been shown to improve symptoms in some patients [114]. Data from eight randomized clinical trials concluded that physical therapy improves exhaustion, quality of sleep, and health status of the patients in the long term, thus showing beneficial potential [12]."