Naloxone inhibits superoxide release from human neutrophils

[Mister Person]

Perhaps this is another mechanism for LDN? I don't understand. Younger mentioned nadph oxidase, astrocytes, opiod growth factor, and the rebound endorphin. But no mention of this neutrophil paper

 

[Trish]

I assume you are referring to this paper from 1985:
Naloxone inhibits superoxide release from human neutrophils
Simpkins et al.
Abstract
Using the superoxide dismutase inhibitable reduction of cytochrome c assay, we studied, the effect of (-) naloxone on N-formyl-methionyl-leucyl-phenylalanine (FMLP) stimulated superoxide (O2-) release from human neutrophils. Neutrophils were pre-incubated with the range of concentrations of (-) naloxone that is administered in models of experimental sepsis (10(-6) - 10(-4.5) M). (-) Naloxone inhibited O2- release in a dose dependent manner. 02- produced by a cell-free xanthine-xanthine oxidase system was not inhibited by (-) naloxone, indicating that (-) naloxone was not scavanging O2-. There was no difference between the effect of (-) and (+) naloxone suggesting that the inhibition of O2- was not specific for an opiate receptor. Another opiate antagonist, nalorphine, as well as the opiate agonist, morphine, also inhibited O2- release in the same concentration range. There was no difference between the effect of naloxone and morphine.
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Note that LDN is Low Dose Naltrexone, not naloxone.

From WebMD

Naloxone vs. Naltrexone
Written by Marijke Vroomen Durning, RN
Medically Reviewed by Smitha Bhandari, MD on April 29, 2022

Naloxone (Narcan, Evzio) and naltrexone (ReVia, Depade) are two drugs used to help people with opioid addictions. They’re both in a class of drugs called opioid antagonists, but they do different things.

What Are Naloxone and Naltrexone?
Naloxone is a drug that can temporarily reverse the effects of an opioid overdose. Anyone can give this very fast-acting medication, as a shot or nasal spray. It can save lives if it’s given quickly enough.

Naltrexone is not an emergency drug. It’s prescribed as part of a treatment plan to help you stop using a drug or consuming alcohol if you have a substance use disorder.

How Do Opioid Antagonists Work?
When you take an opioid, it binds to opioid receptors in your brain. Opioid receptors help your body control pain and addictive behavior. Opioid antagonists block the opioids from binding to those receptors, keeping the drug from causing the euphoria, or “high.”