Nature: ‘It’s all gone’: CAR-T therapy forces autoimmune diseases into remission

I only ever met one person who had rheumatoid arthritis, an English woman who had moved to France with her family because she found better healthcare here. She said that when she has a rituximab injection, she feels so much better that she could go and run a marathon.

 

It is IgG and it is a substantial subset with antibodies against specific paranodal proteins.

In any case, the efficacy is when there is ongoing damage, rather than past damage.

 

Successful use of anti-CD19 CAR T cells in severe treatment-refractory stiff-person syndrome

https://www.pnas.org/doi/full/10.1073/pnas.2403227121

There's a pre/post video of the person's gait in the link provided.

SPS is the autoimmune condition that forced Celine Dion off stage by the way.

 

Seems like every nut is being cracked except for ME/CFS.