Nervous system-related tropism of SARS-CoV-2 and autoimmunity in COVID-19 infection, 2023, Robert Weissert

[EndME]

Nervous system-related tropism of SARS-CoV-2 and autoimmunity in COVID-19 infection

Abstract
The effects of SARS-CoV-2 in COVID-19 on the nervous system are incompletely understood. SARS-CoV-2 can infect endothelial cells, neurons, astrocytes, and oligodendrocytes with consequences for the host. There are indications that infection of these central nervous system-resident cells may result in long term effects, including emergence of neurodegenerative diseases. Indirect effects of infection with SARS-CoV-2 relate to the induction of autoimmune disease involving molecular mimicry or/and bystander activation of T- and B cells and emergence of autoantibodies against various self-antigens. Data obtained in preclinical models of coronavirus induced disease gives important clues for understanding of nervous system related assault of SARS-CoV-2. The pathophysiology of long-COVID syndrome and post-COVID syndrome in which autoimmunity and immune dysregulation might be the driving forces are still incompletely understood. Better understanding of nervous-system-related immunity in COVID-19 might support development of therapeutic approaches. In this review, the current understanding of SARS-CoV-2 tropism for the nervous system, the associated immune responses and diseases are summarized.

The data indicates that there is viral tropism of SARS-CoV-2 for the nervous system resulting into various disease conditions. Prevention of SARS-CoV-2 infection by means of vaccination is currently the best strategy for prevention of subsequent tissue damage involving the nervous system.


https://onlinelibrary.wiley.com/doi/10.1002/eji.202250230

 

[rvallee]

Prevention of SARS-CoV-2 infection by means of vaccination

But COVID vaccines don't prevent infections. They reduce the severity of illness and reduce transmission but they don't prevent them. And vaccine uptake is abysmal and will keep getting lower because of constant minimization, basing the entire messaging around the pandemic around fear instead of the actual virus, literally encouraging infections as not only good but necessary for good health, which basically sets back public health 2 centuries.

There may be a case to say that if this were 100% dutifully followed it would work out somewhat, although proper ventilation and basic measures would have far greater impact, but this is like suggesting we could eradicate AIDS if everyone stopped having sex. We have to work with the reality we have, not something straight out of imagination. Not only is it not the best strategy, it's not even a viable one.

There is no evidence that vaccination reduces tropism. It probably does indirectly by reducing the viruses' ability to spread in the body, but it is simply not a viable strategy, and prevention is not going to happen anymore, not for decades. That ship has sailed and sunk completely. Any attempt to use such measures again will be met with huge backlash, people screaming mad, ranting about how they "will not comply!" and other nonsense. It's going to get real ugly and the people responsible for this will never even notice their own role in it, will never be held accountable, and will continue to be the only "experts" who are listened to.

In fact, vaccine uptake in general will drop massively in coming years because of this. Pinning everything on a very imperfect tool in conditions that don't even allow it to work half as effectively as it could is ridiculous. Science cannot limit itself to labs, it has to account for reality as it is happening out there.