Abstract Objective To describe neurologic, radiologic and laboratory features in children with central nervous system (CNS) inflammatory disease complicating SARS-CoV-2 infection. Study design We focused on CNS inflammatory diseases in children referred from 12 hospitals in the Paris area to Necker-Enfants Malades Reference Centre. Results We identified 19 children who had a history of SARS-CoV-2 infection and manifest a variety of CNS inflammatory diseases: encephalopathy, cerebellar ataxia, ADEM, neuromyelitis optica spectrum disorder (NMOSD) or optic neuritis. All patients had a history of SARS-CoV-2 exposure, and all tested positive for circulating antibodies against SARS-CoV-2. At the onset of the neurologic disease, SARS-CoV-2 PCR results (nasopharyngeal swabs) were positive in 8 children. Cerebrospinal fluid was abnormal in 58% (11/19), MRI was abnormal in 74% (14/19). We identified an autoantibody co-trigger in 4 children (MOG and AQP4 antibodies) representing 21%. No autoantibody was found in the 6 children whose CNS inflammation was accompanied by a multisystem inflammatory syndrome in children (MIS-C). Overall, 89% of patients (17/19) received anti-inflammatory treatment, primarily high-pulse methylprednisolone. All patients had a complete long-term recovery and, to date, no patient with autoantibodies presented with a relapse. Conclusion SARS2-CoV-2 represents a new trigger of post infectious CNS inflammatory diseases in children. Open access, https://www.jpeds.com/article/S0022-3476(22)00426-7/fulltext
