News in Brief - April 2026
- Thread starter S4ME News
- Start date
Week beginning 6th April 2026
News, advocacy and articles
Norwegian Guidelines A draft for guidelines on fatigue and ME/CFS is currently under public consultation and receiving a lot of criticism. The ME researchers Olav Mella, Øystein Fluge and Karl Johan Tronstad have written an opinion piece with several important critical points where they argue for a new revision of the guidelines with a clear scope on ME, a broader review of the scientific literature and a better embedding of international guidelines.
Opinion piece (Norwegian) l Thread
OECD
The Organisation for Economic Cooperation and Development (OECD) has published a detailed report on Long Covid, calling it the "the long shadow of the pandemic". It estimates GDP losses of 0.1-0.2% due to Long Covid, which could create "a major drag on the economy amounting to USD 135 billion per annum over the next decade."
Report | Thread
UK Hope for ME and Fibro Northern Ireland Videos are now available from the Newry conference 'Collaboration for Change' held on 27th March. Speakers include Professors Chris Ponting and Tom Trinick and Dr William Weir.
Videos | Thread
Canada The Canadian Pain Society's 2026 conference presented two posters from the McMaster group. One is a clinical practice guideline on physical activity for ME/CFS and the other is about benefits and harms of physical activity for ME/CFS patients. Both of them unfortunately endorse exercise therapy as treatment.
Thread
...............
Crowdfunding
Trial By Error Reporting on ME, ME/CFS, Long COVID, & so on ...
David Tuller is crowdfunding for the final time to continue his position and important work until he plans to retire from Berkeley University at the end of this year. The goal is to raise $75,000 by 5th May.
Crowdfunding l Thread
.............
Coming events
Solve ME Webinar The Discovery of Target Antigens for Dysfunctional T Cells in ME/CFS and Long COVID
Thursday, April 28, 3:00 pm Pacific / 6:00 pm Eastern
Announcement | Registration | Thread
UK Durham University Gender, affective injustice & ‘the greatest medical scandal of the 21st century'
Talk by Dr Katharine Cheston on Monday, May 11, 12 PM - 1:30 PM
Dr Cheston worked with Action for ME on their 2025 Big Survey.
"Drawing on preliminary analysis of the Big Survey data, alongside semi-structured interviews conducted during my PhD, I will interrogate this scandal, illuminate its gendered dimensions, and demonstrate how it constitutes a compelling case study of affective injustice in healthcare."
Free Zoom booking | Thread
.............
Research news and commentary
USA RECOVER-TLC announces public comment period for upcoming clinical trial
"RECOVER-Treating Long COVID (RECOVER-TLC) invites patients, caregivers, advocates, healthcare providers, and researchers to provide feedback on the draft protocol synopsis for its upcoming glucagon-like peptide-1 receptor agonist (GLP-1 RA) clinical trial."
Website l Thread
............
Research
ME/CFS research
Perioperative outcomes in myalgic encephalomyelitis/chronic fatigue syndrome undergoing general anesthesia: a retrospective matched-pair study — Felix M Steinkirchner et al
"ME/CFS represents a potentially vulnerable population that remains underrepresented in the anesthesia literature and for whom evidence-based perioperative guidance is currently lacking." "Overall, general anesthesia appeared to be well tolerated from a hemodynamic perspective, whereas postoperative recovery, particularly pain, was more adversely affected compared with matched controls."
Preprint | Thread
Validation of the Wood Mental Fatigue Inventory in adolescents with myalgic encephalomyelitis/chronic fatigue syndrome — Welch et al
"Cohen's d was large for both the WMFI (1.83) and the Peds QL MFS cognitive fatigue subscale (1.95), indicating that the means between the ME/CFS patients and the healthy controls on both questionnaires differed by more than 1.8 times the baseline standard deviation."
Article | Thread
Long Covid research
Longitudinal study of genome-wide DNA methylation in individuals with and without post-acute symptoms following SARS-CoV-2 infection — Jon Bohlin et al
"Using a longitudinal design with matched samples, collected before and after infection, we analyzed genome-wide DNA methylation in 297 adults." "We found no evidence of genome-wide DNA methylation differences associated with COVID-19 infection or persistent Long-COVID symptoms."
Article | Thread
Immune correlates underlying small fiber neuropathy presenting as vaccine-associated post-acute SARS- coronavirus syndrome — Limongelli et al
"we describe a cohort of patients with postvaccine PASC satisfying SFN definition criteria, for whom an underlying persistent inflammation (evidenced by CD34+DNAM1bright cells) was observed, along with a peripheral expansion of innate-like T cells"
Article | Thread
Clinically confirmed cohort reveals antioxidant genetic polymorphisms as potential susceptibility factors for long COVID after mild or asymptomatic COVID-19 — Katsarou et al
"SOD2 and EPHX1 variants are associated with Long COVID susceptibility."
Article | Thread
The effect of pre-existing sleep disturbance on T cell responses to SARS-CoV-2 variants, pro-inflammatory and pro-resolving mediators, and glucocorticoid sensitivity in Long COVID — Haack et al
"These exploratory findings suggest that preexisting sleep disturbance may be associated with compromised glucocorticoid mediated inflammatory suppression in a subset of individuals classified as Likely LC."
Article | Thread
Dysautonomia in Long COVID is Prevalent and Could Explain the Frequency of Symptoms — Leonardo Tamariz et al
"Orthostatic hypotension was observed in 12% of the study population, and postural orthostatic tachycardia syndrome (POTS) was seen in 10%" "Measures of exercise induced dysautonomia were seen in 57% among the 25 long COVID patients who had a CPET."
Article | Thread
School Difficulties and Long COVID in Children and Adolescents — Harrison T. Reeder et al
"These findings also provide evidence of a key disruption of functional status at critical points in the life course, which have profound implications both for the future health of this generation and for public policy."
Article | Thread
............
S4ME social media: Forum, Mastodon, Bluesky
News, advocacy and articles
Norwegian Guidelines A draft for guidelines on fatigue and ME/CFS is currently under public consultation and receiving a lot of criticism. The ME researchers Olav Mella, Øystein Fluge and Karl Johan Tronstad have written an opinion piece with several important critical points where they argue for a new revision of the guidelines with a clear scope on ME, a broader review of the scientific literature and a better embedding of international guidelines.
Opinion piece (Norwegian) l Thread
OECD
The Organisation for Economic Cooperation and Development (OECD) has published a detailed report on Long Covid, calling it the "the long shadow of the pandemic". It estimates GDP losses of 0.1-0.2% due to Long Covid, which could create "a major drag on the economy amounting to USD 135 billion per annum over the next decade."
Report | Thread
UK Hope for ME and Fibro Northern Ireland Videos are now available from the Newry conference 'Collaboration for Change' held on 27th March. Speakers include Professors Chris Ponting and Tom Trinick and Dr William Weir.
Videos | Thread
Canada The Canadian Pain Society's 2026 conference presented two posters from the McMaster group. One is a clinical practice guideline on physical activity for ME/CFS and the other is about benefits and harms of physical activity for ME/CFS patients. Both of them unfortunately endorse exercise therapy as treatment.
Thread
...............
Crowdfunding
Trial By Error Reporting on ME, ME/CFS, Long COVID, & so on ...
David Tuller is crowdfunding for the final time to continue his position and important work until he plans to retire from Berkeley University at the end of this year. The goal is to raise $75,000 by 5th May.
Crowdfunding l Thread
.............
Coming events
Solve ME Webinar The Discovery of Target Antigens for Dysfunctional T Cells in ME/CFS and Long COVID
Thursday, April 28, 3:00 pm Pacific / 6:00 pm Eastern
Announcement | Registration | Thread
UK Durham University Gender, affective injustice & ‘the greatest medical scandal of the 21st century'
Talk by Dr Katharine Cheston on Monday, May 11, 12 PM - 1:30 PM
Dr Cheston worked with Action for ME on their 2025 Big Survey.
"Drawing on preliminary analysis of the Big Survey data, alongside semi-structured interviews conducted during my PhD, I will interrogate this scandal, illuminate its gendered dimensions, and demonstrate how it constitutes a compelling case study of affective injustice in healthcare."
Free Zoom booking | Thread
.............
Research news and commentary
USA RECOVER-TLC announces public comment period for upcoming clinical trial
"RECOVER-Treating Long COVID (RECOVER-TLC) invites patients, caregivers, advocates, healthcare providers, and researchers to provide feedback on the draft protocol synopsis for its upcoming glucagon-like peptide-1 receptor agonist (GLP-1 RA) clinical trial."
Website l Thread
............
Research
ME/CFS research
Perioperative outcomes in myalgic encephalomyelitis/chronic fatigue syndrome undergoing general anesthesia: a retrospective matched-pair study — Felix M Steinkirchner et al
"ME/CFS represents a potentially vulnerable population that remains underrepresented in the anesthesia literature and for whom evidence-based perioperative guidance is currently lacking." "Overall, general anesthesia appeared to be well tolerated from a hemodynamic perspective, whereas postoperative recovery, particularly pain, was more adversely affected compared with matched controls."
Preprint | Thread
Validation of the Wood Mental Fatigue Inventory in adolescents with myalgic encephalomyelitis/chronic fatigue syndrome — Welch et al
"Cohen's d was large for both the WMFI (1.83) and the Peds QL MFS cognitive fatigue subscale (1.95), indicating that the means between the ME/CFS patients and the healthy controls on both questionnaires differed by more than 1.8 times the baseline standard deviation."
Article | Thread
Long Covid research
Longitudinal study of genome-wide DNA methylation in individuals with and without post-acute symptoms following SARS-CoV-2 infection — Jon Bohlin et al
"Using a longitudinal design with matched samples, collected before and after infection, we analyzed genome-wide DNA methylation in 297 adults." "We found no evidence of genome-wide DNA methylation differences associated with COVID-19 infection or persistent Long-COVID symptoms."
Article | Thread
Immune correlates underlying small fiber neuropathy presenting as vaccine-associated post-acute SARS- coronavirus syndrome — Limongelli et al
"we describe a cohort of patients with postvaccine PASC satisfying SFN definition criteria, for whom an underlying persistent inflammation (evidenced by CD34+DNAM1bright cells) was observed, along with a peripheral expansion of innate-like T cells"
Article | Thread
Clinically confirmed cohort reveals antioxidant genetic polymorphisms as potential susceptibility factors for long COVID after mild or asymptomatic COVID-19 — Katsarou et al
"SOD2 and EPHX1 variants are associated with Long COVID susceptibility."
Article | Thread
The effect of pre-existing sleep disturbance on T cell responses to SARS-CoV-2 variants, pro-inflammatory and pro-resolving mediators, and glucocorticoid sensitivity in Long COVID — Haack et al
"These exploratory findings suggest that preexisting sleep disturbance may be associated with compromised glucocorticoid mediated inflammatory suppression in a subset of individuals classified as Likely LC."
Article | Thread
Dysautonomia in Long COVID is Prevalent and Could Explain the Frequency of Symptoms — Leonardo Tamariz et al
"Orthostatic hypotension was observed in 12% of the study population, and postural orthostatic tachycardia syndrome (POTS) was seen in 10%" "Measures of exercise induced dysautonomia were seen in 57% among the 25 long COVID patients who had a CPET."
Article | Thread
School Difficulties and Long COVID in Children and Adolescents — Harrison T. Reeder et al
"These findings also provide evidence of a key disruption of functional status at critical points in the life course, which have profound implications both for the future health of this generation and for public policy."
Article | Thread
............
S4ME social media: Forum, Mastodon, Bluesky
Week beginning 13th April 2026
News, advocacy and articles
ME/CFS Research Preview
Simon McGrath explains how an analysis of survey data on patients across Europe found that there are two peak ages for getting ME/CFS, around 16 and the late 30s – a rare bimodal pattern.
Article | Thread
Open Medicine Foundation A new chapter in ME/CFS treatment research begins today—and your voice is essential to making it count
Open Medicine Foundation (OMF) has launched a research model they are calling CTN Lite. Unlike a traditional clinical trials network (CTN) OMF is trying to create a streamlined model which will lead to answers faster. Patients and caregivers are asked to take a short survey about research priorities. This survey will be available until May 15.
Article | Survey | Thread
The Sick Times I developed Long COVID while practicing medicine. The system had no place for me
An important essay from internal medicine resident Mustafa Talat: "Medical institutions must educate staff that Long COVID is a disabling condition affecting up to 40% of healthcare workers who contracted and continue to contract COVID-19 while working in hospitals that have failed to control the spread of the virus and other pathogens."
Article l Thread
#MEAction to Meet with NIH Director during #MillionsMissing Week
NIH Director Bhattacharya will meet with #MEAction on May 13 to discuss the implementation plan and funding for the NIH ME/CFS Research Roadmap.
Article | Thread
..........
Crowdfunding
Trial By Error Reporting on ME, ME/CFS, Long COVID, & so on...
David Tuller is crowdfunding for the final time to continue his position and important work until he plans to retire from Berkeley University at the end of this year. The goal is to raise $ 75 000 by 5th May.
Crowdfunding l Thread
...........
Coming events
Bateman Horne Center Free Online Support Group
Tuesday, April 21, 1 - 2 pm MDT
Topic: Who am I Now? Identity and Chronic Illness
Advance registration required, registration link shows time in your time zone.
Registration | Thread
Solve ME Webinar The Discovery of Target Antigens for Dysfunctional T Cells in ME/CFS and Long COVID
Thursday, April 28, 3 pm PDT / 6 pm EDT
Announcement | Registration | Thread
Durham University - Institute for Medical Humanities Gender, affective injustice & ‘the greatest medical scandal of the 21st century'
Monday, May 11, 12 pm - 1:30 pm BST
Katharine Cheston discusses the treatment of people with ME and its wider implications in terms of affective injustice in healthcare. Event is free, register to reserve a spot. A Zoom link will be circulated closer to the event.
Announcement | Registration | Thread
...........
Research news and commentary
Australia MRFF 2026 PASC grant opportunity
The Department of Health, Disability and Ageing's Medical Research Future Fund is providing up to $23 million for medical research and innovation projects. The projects can investigate biological pathways, carry out pre-clinical or early-phase clinical research into mechanisms and therapeutics, compare the underlying causes of PASC with other postviral chronic illnesses, or identify scalable, sustainable integrated care approaches.
Announcement | Thread
Solve ME What's New in ME/CFS? Interview with Dr. Avik Roy & Dr. Gunnar Gottschalk (Simmaron Research)
Article | Video | Thread
Solve ME has posted a recording from their April 16 webinar (“GLP-1 Drugs to Reduce Symptoms in People with ME/CFS and Identify Disease Subgroups”) on their YouTube channel.
Video | Thread
...........
Research
ME/CFS research
Insights into Pathophysiological Pathways in ME/CFS Through Genetic Correlation and Mendelian Randomization — Wielscher et al
"findings indicate that ME/CFS susceptibility reflects interacting pathways involving barrier–microbiome dysfunction, neurovascular instability, inflammation, platelet activation, and impaired cellular energetics"
Preprint | Thread
3D Virtual Reality Performance Metrics as a Future Fatigue Biomarker in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) — Ladek et al
"VR-OTS RT metrics showed not only considerable differences between healthy controls and patients with ME/CFS, but also different performance patterns over time; thus, some of these metrics may be indicative of PEM and fatigue."
Article | Thread
Making Invisible Illnesses Visible: Recognizing and Responding to Infection Associated Chronic Conditions — Iskander and Haridopolos
From the Office of the U.S. Surgeon General. "Grounds for optimism in this emerging field include calls from public health leaders to break down silos between infectious and chronic conditions, new data and emphasis on IACCI from the Centers for Disease Control and Prevention"
Article | Thread
Comparing ME/CFS following mononucleosis with Long COVID — Jason et al
"for the definition of Long COVID only 3 months of symptoms are required" "In general, the Long COVID group’s symptom burden was less than that of the Severe ME/CFS group"
Article | Thread
Long Covid research
Distinct plasma proteome signature at 3 months post-COVID-19 infection irrespective of post-COVID condition — Chowdhury et al
"even after mild infection, the plasma proteomic signature of uninfected individuals differs substantially from that of both convalescent and PCC groups." "differences between the convalescent and PCC groups are subtle, suggesting that persistent proteomic alterations occur after mild COVID-19 but may not fully explain PCC-specific symptomatology."
Article | Thread
Association of ADIPOQ rs1501299 with long-COVID syndrome: a single-center cross-sectional study — Mavroudis et al
"the homozygous GG genotype increased the risk for fatigue as a Long-COVID symptom, compared to T allele carriers (OR 2.4, 95% CI 1.2, 5.0, p = 0.014)." "This correlation was also independent of age, sex, BMI, waist to hip ratio, severity of the acute disease and any of the comorbidities."
Article | Thread
............
S4ME social media: Forum, Mastodon, Bluesky
News, advocacy and articles
ME/CFS Research Preview
Simon McGrath explains how an analysis of survey data on patients across Europe found that there are two peak ages for getting ME/CFS, around 16 and the late 30s – a rare bimodal pattern.
Article | Thread
Open Medicine Foundation A new chapter in ME/CFS treatment research begins today—and your voice is essential to making it count
Open Medicine Foundation (OMF) has launched a research model they are calling CTN Lite. Unlike a traditional clinical trials network (CTN) OMF is trying to create a streamlined model which will lead to answers faster. Patients and caregivers are asked to take a short survey about research priorities. This survey will be available until May 15.
Article | Survey | Thread
The Sick Times I developed Long COVID while practicing medicine. The system had no place for me
An important essay from internal medicine resident Mustafa Talat: "Medical institutions must educate staff that Long COVID is a disabling condition affecting up to 40% of healthcare workers who contracted and continue to contract COVID-19 while working in hospitals that have failed to control the spread of the virus and other pathogens."
Article l Thread
#MEAction to Meet with NIH Director during #MillionsMissing Week
NIH Director Bhattacharya will meet with #MEAction on May 13 to discuss the implementation plan and funding for the NIH ME/CFS Research Roadmap.
Article | Thread
..........
Crowdfunding
Trial By Error Reporting on ME, ME/CFS, Long COVID, & so on...
David Tuller is crowdfunding for the final time to continue his position and important work until he plans to retire from Berkeley University at the end of this year. The goal is to raise $ 75 000 by 5th May.
Crowdfunding l Thread
...........
Coming events
Bateman Horne Center Free Online Support Group
Tuesday, April 21, 1 - 2 pm MDT
Topic: Who am I Now? Identity and Chronic Illness
Advance registration required, registration link shows time in your time zone.
Registration | Thread
Solve ME Webinar The Discovery of Target Antigens for Dysfunctional T Cells in ME/CFS and Long COVID
Thursday, April 28, 3 pm PDT / 6 pm EDT
Announcement | Registration | Thread
Durham University - Institute for Medical Humanities Gender, affective injustice & ‘the greatest medical scandal of the 21st century'
Monday, May 11, 12 pm - 1:30 pm BST
Katharine Cheston discusses the treatment of people with ME and its wider implications in terms of affective injustice in healthcare. Event is free, register to reserve a spot. A Zoom link will be circulated closer to the event.
Announcement | Registration | Thread
...........
Research news and commentary
Australia MRFF 2026 PASC grant opportunity
The Department of Health, Disability and Ageing's Medical Research Future Fund is providing up to $23 million for medical research and innovation projects. The projects can investigate biological pathways, carry out pre-clinical or early-phase clinical research into mechanisms and therapeutics, compare the underlying causes of PASC with other postviral chronic illnesses, or identify scalable, sustainable integrated care approaches.
Announcement | Thread
Solve ME What's New in ME/CFS? Interview with Dr. Avik Roy & Dr. Gunnar Gottschalk (Simmaron Research)
Article | Video | Thread
Solve ME has posted a recording from their April 16 webinar (“GLP-1 Drugs to Reduce Symptoms in People with ME/CFS and Identify Disease Subgroups”) on their YouTube channel.
Video | Thread
...........
Research
ME/CFS research
Insights into Pathophysiological Pathways in ME/CFS Through Genetic Correlation and Mendelian Randomization — Wielscher et al
"findings indicate that ME/CFS susceptibility reflects interacting pathways involving barrier–microbiome dysfunction, neurovascular instability, inflammation, platelet activation, and impaired cellular energetics"
Preprint | Thread
3D Virtual Reality Performance Metrics as a Future Fatigue Biomarker in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) — Ladek et al
"VR-OTS RT metrics showed not only considerable differences between healthy controls and patients with ME/CFS, but also different performance patterns over time; thus, some of these metrics may be indicative of PEM and fatigue."
Article | Thread
Making Invisible Illnesses Visible: Recognizing and Responding to Infection Associated Chronic Conditions — Iskander and Haridopolos
From the Office of the U.S. Surgeon General. "Grounds for optimism in this emerging field include calls from public health leaders to break down silos between infectious and chronic conditions, new data and emphasis on IACCI from the Centers for Disease Control and Prevention"
Article | Thread
Comparing ME/CFS following mononucleosis with Long COVID — Jason et al
"for the definition of Long COVID only 3 months of symptoms are required" "In general, the Long COVID group’s symptom burden was less than that of the Severe ME/CFS group"
Article | Thread
Long Covid research
Distinct plasma proteome signature at 3 months post-COVID-19 infection irrespective of post-COVID condition — Chowdhury et al
"even after mild infection, the plasma proteomic signature of uninfected individuals differs substantially from that of both convalescent and PCC groups." "differences between the convalescent and PCC groups are subtle, suggesting that persistent proteomic alterations occur after mild COVID-19 but may not fully explain PCC-specific symptomatology."
Article | Thread
Association of ADIPOQ rs1501299 with long-COVID syndrome: a single-center cross-sectional study — Mavroudis et al
"the homozygous GG genotype increased the risk for fatigue as a Long-COVID symptom, compared to T allele carriers (OR 2.4, 95% CI 1.2, 5.0, p = 0.014)." "This correlation was also independent of age, sex, BMI, waist to hip ratio, severity of the acute disease and any of the comorbidities."
Article | Thread
............
S4ME social media: Forum, Mastodon, Bluesky
Week beginning 20th April 2026
News, advocacy and articles
Germany A freedom of information request to the Department of Life Sciences in the Ministry of Research asked for Long Covid and ME/CFS correspondence within the department. "577 pages from the Ministry of Research — with extensive redactions. We are publishing the documents for the first time today and continue working to make the contents fully accessible. Even now it is clear: In the responsible Life Sciences department there were years of delays and obstructions."
Tweet | FOI request and response | Thread
France
Members of Winslow Santé Publique have disrupted a Long Covid conference in Paris, organised by Cédric Lemogne and Briggite Ranque. The activists denounced the researchers for psychologizing Long Covid, wasting research funds, and not involving patients in their conference.
Article | Thread
New Scientist Exercise advice for long covid may be doing more harm than good
Informative article on the harmful use of exercise as treatment for patients with PEM and on criticism of the research behind this approach. Includes interviews with David Tuller, Tom Kindlon and more.
Article (archived) l Thread
Trial By Error by David Tuller
Article in New Scientist Questions Value of Exercise for Long COVID (and quotes me)
Praise of the article in New Scientist by journalist Alexandra Thompson on exercise as harmful treatment for patients with PEM. See item above.
Article l Thread
Lancet Journal Published My Letter Challenging Claims on Exercise and Long COVID
David Tuller wrote a letter to eClinicalMedicine on errors in a paper which reported that exercise could improve health in Long Covid. The journal has now published Tuller's letter together with a corrigendum and author response: "we must acknowledge that certain expressions used in our writing, such as 'high-certainty evidence' and 'should be prioritized,' may have come across as overly assertive and could potentially lead to misinterpretation by readers.”
Article | Corrigendum | Authors' Response | Thread
.........
Fundraising
Trial By Error Reporting on ME, ME/CFS, Long COVID, & so on...
David Tuller is crowdfunding for the final time to continue his position and important work until he plans to retire from Berkeley University at the end of this year. The goal is to raise $ 75 000 by 5th May.
Crowdfunding l Thread
UK Action for ME This month’s BBC Lifeline Appeal is made on behalf of Action for ME.
Donate | Thread
..........
Coming events
USA Rooted in Hope Charity Concert - Sunday, April 26 - in person, online and recording. Organized by MECFS Clinic MN & Minnesota ME/CFS Alliance. To raise awareness and funds, free, donations and silent auction.
Booking | Thread
International ME/CFS Conference
The International ME/CFS Conference 2026 will take place in Berlin from 7 to 8 May. The event will be broadcast online live from the Harnack House of the Max Planck Society. Presentations will be held in English and speakers include Christopher Armstrong, Chris Ponting, and Michelle James, among many others.
Article | Thread
Austria
On May 9, a protest will take place in Vienna for International ME/CFS Day. The goal is to send a united message and draw attention to the precarious state of care for those affected by the illness.
Article | Thread
...........
Research
ME/CFS research
Identification of novel reproducible combinatorial genetic risk factors for myalgic encephalomyelitis in the DecodeME patient cohort and commonalities with long COVID — Sardell et al
"Among the core candidate genes identified in our analysis, several are implicated in immune dysregulation and impaired energy metabolism – two key biological mechanisms thought to underlie ME pathophysiology"
Article | Thread
PTPRN2 hypomethylation and PHB2-associated miR-153-3p maturation define dual epigenetic features linked to symptom variability in Myalgic encephalomyelitis — Chalder et al
"findings suggest a link between DNA methylation and miRNA dynamics, providing insight into the molecular landscape of ME pathogenesis and the basis of sex-specific differences in symptom expression." "These observations remain exploratory"
Article | Thread
Facility-Measured Sleep Electroencephalographic Microstructures in Long COVID — Sun et al
"The abnormally early spindle-SO coupling phase in LC was correlated with worse subjective sleep quality. Similar differences in EEG microstructural patterns were found in people with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS)" "results demonstrate candidate electrophysiological abnormalities associated with the fatigue and non-restorative sleep experienced in LC."
Article | Thread
Neurovascular and synaptic milieu of brain-resident cells in cognitive dysfunction of myalgic encephalomyelitis/chronic fatigue syndrome — Xu et al
Review. "current evidence most consistently supports neurovascular dysfunction and glial activation as primary, imaging- and biomarker-supported mechanisms, whereas neuronal network imbalance, oligodendrocyte involvement, and extracellular-vesicle–mediated signaling remain secondary or hypothesis-generating."
Article | Thread
Neuroendocrine signature of ME/CFS: Meta-analytic evidence for bioactive cortisol deficit and exaggerated feedback sensitivity — Woo et al
"Our findings indicate an approximately 20–30% reduction in bioavailable (free) cortisol levels across saliva, urine, and hair, despite stable total blood cortisol levels." "while most observed values remain within the established circadian normal range, these findings reflect a distinct physiological signature of endocrine dysregulation rather than a simple production failure."
Article | Thread
The efficacy of exercise in patients with myalgic encephalomyelitis/chronic fatigue syndrome: A systematic review and meta-analysis — Zhao et al
"our risk of bias assessment using the RoB 2.0 tool indicated a prevalent high risk of bias across the included studies" "subjective benefits do not translate into significant gains in objective cardiopulmonary or functional capacity"
Article | Thread
Investigating the ME/CFS experience through qualitative analysis of memorial entries — Sirotiak and Amro
"This analysis takes an inductive approach to uncover nuances within the memorial data and seek a deeper understanding of the lived experiences and deaths of those with ME/CFS."
Article | Thread
Long Covid research
Impaired peripheral oxygen delivery during submaximal exercise in adults with long COVID — Thomas et al
"LC TSI% remained elevated above rest for a shorter duration of exercise compared to CON, worsening for LC on day 2." "LC showed rapid normalization of TSI%, suggesting impaired muscle oxygenation and recovery during repeated exercise."
Article | Thread
Endovascular profiles linked to neutrophil activation in children and young adults with long COVID — Steifman et al
"these data suggest that children and young adults with long COVID have increased angiogenesis and endothelial injury with containment of inflammatory cells within circulation." "symptom severity stratification did not significantly correlate with levels of cell-free DNA or microclot burden."
Article | Thread
Post-Exertional Malaise in Post-COVID-19 Syndrome: A Shift in the Frequency Across Pandemic Phases — Ghali et al
"PEM was six times more frequent among PCS patients infected in the preOmicron period relative to those infected in the Omicron period."
Article | Thread
The case for routine patient review in long COVID research — Soares et al
"Clear designation that a manuscript has undergone patient review would function as an additional signal of quality, and publication of patient reviews alongside the manuscript would amplify the contents of patient expertise to the broader scientific community."
Article | Thread
Interdisciplinary Pediatric Long-COVID Care: A Descriptive Study of Interventions and Health-Related Quality of Life — Miller et al
"Pediatric patients with long-COVID report high symptom burden, which appears to meet or exceed that of other chronic health conditions (eg, cancer, type 1 diabetes, asthma, and sickle cell disease)."
Article | Thread
............
S4ME social media: Forum, Mastodon, Bluesky
News, advocacy and articles
Germany A freedom of information request to the Department of Life Sciences in the Ministry of Research asked for Long Covid and ME/CFS correspondence within the department. "577 pages from the Ministry of Research — with extensive redactions. We are publishing the documents for the first time today and continue working to make the contents fully accessible. Even now it is clear: In the responsible Life Sciences department there were years of delays and obstructions."
Tweet | FOI request and response | Thread
France
Members of Winslow Santé Publique have disrupted a Long Covid conference in Paris, organised by Cédric Lemogne and Briggite Ranque. The activists denounced the researchers for psychologizing Long Covid, wasting research funds, and not involving patients in their conference.
Article | Thread
New Scientist Exercise advice for long covid may be doing more harm than good
Informative article on the harmful use of exercise as treatment for patients with PEM and on criticism of the research behind this approach. Includes interviews with David Tuller, Tom Kindlon and more.
Article (archived) l Thread
Trial By Error by David Tuller
Article in New Scientist Questions Value of Exercise for Long COVID (and quotes me)
Praise of the article in New Scientist by journalist Alexandra Thompson on exercise as harmful treatment for patients with PEM. See item above.
Article l Thread
Lancet Journal Published My Letter Challenging Claims on Exercise and Long COVID
David Tuller wrote a letter to eClinicalMedicine on errors in a paper which reported that exercise could improve health in Long Covid. The journal has now published Tuller's letter together with a corrigendum and author response: "we must acknowledge that certain expressions used in our writing, such as 'high-certainty evidence' and 'should be prioritized,' may have come across as overly assertive and could potentially lead to misinterpretation by readers.”
Article | Corrigendum | Authors' Response | Thread
.........
Fundraising
Trial By Error Reporting on ME, ME/CFS, Long COVID, & so on...
David Tuller is crowdfunding for the final time to continue his position and important work until he plans to retire from Berkeley University at the end of this year. The goal is to raise $ 75 000 by 5th May.
Crowdfunding l Thread
UK Action for ME This month’s BBC Lifeline Appeal is made on behalf of Action for ME.
Donate | Thread
..........
Coming events
USA Rooted in Hope Charity Concert - Sunday, April 26 - in person, online and recording. Organized by MECFS Clinic MN & Minnesota ME/CFS Alliance. To raise awareness and funds, free, donations and silent auction.
Booking | Thread
International ME/CFS Conference
The International ME/CFS Conference 2026 will take place in Berlin from 7 to 8 May. The event will be broadcast online live from the Harnack House of the Max Planck Society. Presentations will be held in English and speakers include Christopher Armstrong, Chris Ponting, and Michelle James, among many others.
Article | Thread
Austria
On May 9, a protest will take place in Vienna for International ME/CFS Day. The goal is to send a united message and draw attention to the precarious state of care for those affected by the illness.
Article | Thread
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Research
ME/CFS research
Identification of novel reproducible combinatorial genetic risk factors for myalgic encephalomyelitis in the DecodeME patient cohort and commonalities with long COVID — Sardell et al
"Among the core candidate genes identified in our analysis, several are implicated in immune dysregulation and impaired energy metabolism – two key biological mechanisms thought to underlie ME pathophysiology"
Article | Thread
PTPRN2 hypomethylation and PHB2-associated miR-153-3p maturation define dual epigenetic features linked to symptom variability in Myalgic encephalomyelitis — Chalder et al
"findings suggest a link between DNA methylation and miRNA dynamics, providing insight into the molecular landscape of ME pathogenesis and the basis of sex-specific differences in symptom expression." "These observations remain exploratory"
Article | Thread
Facility-Measured Sleep Electroencephalographic Microstructures in Long COVID — Sun et al
"The abnormally early spindle-SO coupling phase in LC was correlated with worse subjective sleep quality. Similar differences in EEG microstructural patterns were found in people with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS)" "results demonstrate candidate electrophysiological abnormalities associated with the fatigue and non-restorative sleep experienced in LC."
Article | Thread
Neurovascular and synaptic milieu of brain-resident cells in cognitive dysfunction of myalgic encephalomyelitis/chronic fatigue syndrome — Xu et al
Review. "current evidence most consistently supports neurovascular dysfunction and glial activation as primary, imaging- and biomarker-supported mechanisms, whereas neuronal network imbalance, oligodendrocyte involvement, and extracellular-vesicle–mediated signaling remain secondary or hypothesis-generating."
Article | Thread
Neuroendocrine signature of ME/CFS: Meta-analytic evidence for bioactive cortisol deficit and exaggerated feedback sensitivity — Woo et al
"Our findings indicate an approximately 20–30% reduction in bioavailable (free) cortisol levels across saliva, urine, and hair, despite stable total blood cortisol levels." "while most observed values remain within the established circadian normal range, these findings reflect a distinct physiological signature of endocrine dysregulation rather than a simple production failure."
Article | Thread
The efficacy of exercise in patients with myalgic encephalomyelitis/chronic fatigue syndrome: A systematic review and meta-analysis — Zhao et al
"our risk of bias assessment using the RoB 2.0 tool indicated a prevalent high risk of bias across the included studies" "subjective benefits do not translate into significant gains in objective cardiopulmonary or functional capacity"
Article | Thread
Investigating the ME/CFS experience through qualitative analysis of memorial entries — Sirotiak and Amro
"This analysis takes an inductive approach to uncover nuances within the memorial data and seek a deeper understanding of the lived experiences and deaths of those with ME/CFS."
Article | Thread
Long Covid research
Impaired peripheral oxygen delivery during submaximal exercise in adults with long COVID — Thomas et al
"LC TSI% remained elevated above rest for a shorter duration of exercise compared to CON, worsening for LC on day 2." "LC showed rapid normalization of TSI%, suggesting impaired muscle oxygenation and recovery during repeated exercise."
Article | Thread
Endovascular profiles linked to neutrophil activation in children and young adults with long COVID — Steifman et al
"these data suggest that children and young adults with long COVID have increased angiogenesis and endothelial injury with containment of inflammatory cells within circulation." "symptom severity stratification did not significantly correlate with levels of cell-free DNA or microclot burden."
Article | Thread
Post-Exertional Malaise in Post-COVID-19 Syndrome: A Shift in the Frequency Across Pandemic Phases — Ghali et al
"PEM was six times more frequent among PCS patients infected in the preOmicron period relative to those infected in the Omicron period."
Article | Thread
The case for routine patient review in long COVID research — Soares et al
"Clear designation that a manuscript has undergone patient review would function as an additional signal of quality, and publication of patient reviews alongside the manuscript would amplify the contents of patient expertise to the broader scientific community."
Article | Thread
Interdisciplinary Pediatric Long-COVID Care: A Descriptive Study of Interventions and Health-Related Quality of Life — Miller et al
"Pediatric patients with long-COVID report high symptom burden, which appears to meet or exceed that of other chronic health conditions (eg, cancer, type 1 diabetes, asthma, and sickle cell disease)."
Article | Thread
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S4ME social media: Forum, Mastodon, Bluesky
Week beginning 27th April 2026
News, advocacy and articles
Medscape Biological Evidence May Reshape Long-COVID Diagnosis and Care
About a summary of current evidence provided by Christian Gogoll, MD and Carmen Scheibenbogen, MD at the 132nd Congress of the German Society for Internal Medicine in Germany.
Article l Thread
#MEAction Mayo Algorithm’s Effect on ME/CFS Care
A new research paper has been published which evaluates the "care process algorithm for ME/CFS" added to the AskMayoExpert tool. This article also discusses other collaborative work that #MEAction has done with the Mayo Clinic.
Article | Thread
#MEAction $15K Matching Grant for Emergency Department Project
#MEAction received a $15,000 anonymous matching grant to fund their project to improve how people with ME/CFS and Long Covid are treated in emergency care settings.
Article | Thread
Bateman Horne Center has published their spring newsletter (May 2026).
Newsletter (PDF) | Thread
...........
Fundraising
Trial By Error Reporting on ME, ME/CFS, Long COVID, & so on...
Final week of the fundraising.
David Tuller is crowdfunding for the final time to continue his position and important work until he plans to retire from Berkeley University at the end of this year. The goal is to raise $ 75,000 by 8th May.
Crowdfunding l Thread
............
Coming events
Bateman Horne Center Free Online Support Group
Tuesday, May 5, 1 - 2 pm MDT
Topic: What’s the Meaning of All of This? Creating Purpose Out of the Illness Experience
Advance registration required, registration link shows time in your time zone.
Registration | Thread
Bateman Horne Center "Coffee" with a Clinician
Wednesday, May 13, 10 am MDT (9 am PT / 11 am CT / 12 pm ET)
Topic: Post-Exertional Malaise, Part 3
Free to attend, optional $5 donation.
Registration | Thread
...........
Research news and commentary
Australia Call for patient volunteers in Melbourne
La Trobe University study on platelet microRNAs in women. "We need ~25 more women with LC and ~5 more women with ME/CFS in Victoria".
Contact Enrolment | Thread
USA - NIH RECOVER R3 Seminar Recap: Impact of Long COVID on neurocognitive function
An update from the NIH about the April 14 seminar. A recording of the seminar is included.
Article | Video | Thread
Solve ME Systematic Underfunding of Long Covid, ME/CFS, and Other Debilitating Diseases That Disproportionately Affect Women
A "Science Spotlight" article that discusses Dr. Bonuck's recent paper on Long COVID disability burden in the US.
Article | Thread
Solve ME has posted a recording from their April 28 webinar (“The Discovery of Target Antigens for Dysfunctional T Cells in ME/CFS and Long COVID”) on their YouTube channel.
Video | Thread
..........
Research
ME/CFS research
Cardiopulmonary Exercise Testing Reveals Functional Limitations and Work Disability in Severe Post-COVID-19 and ME/CFS Patients — Tomaskovic et al
"Together, these findings suggest that functional limitations in this cohort are primarily driven by suboptimal oxygen uptake efficiency rather than central cardiac or pulmonary pathology."
Article | Thread
Symptom clusters in ME/CFS reflect distinct neuroimmune and autonomic pathophysiological mechanisms: a translational model — Habermann-Horstmeier and Horstmeier
"The proposed interpretations of underlying mechanisms derive from the integration of existing literature and were not directly measured in this study. The identified clusters therefore indicate mechanistic alignment rather than direct mechanistic validation."
Article | Thread
Health, labour market, and social service outcomes for people with Myalgic Encephalomyelitis / Chronic Fatigue Syndrome on a health or disability related benefit: an Aotearoa | New Zealand nationwide cross-sectional study using the integrated data infrastructure — Bowden et al
"Together, these findings highlight a population experiencing sustained health burden and economic vulnerability, and underscore the need for more systematic diagnostic capture and more equitable policy responses for people living with ME/CFS in NZ."
Article | Thread
Underuse of Pharmacologic Therapies for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Before Specialist Evaluation — Grach et al
"Our findings are also consistent with patient reports of clinicians being more likely to target mood concerns, as symptoms may often be labeled psychological before the actual diagnosis of ME/CFS is determined."
Article | Thread
Improving Diagnostic Accuracy of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Through a Point-of-Care Clinical Algorithm — Seltzer et al
"Between publication of the clinical tool and the end of the calendar year, 580 healthcare professionals accessed the tool, referral concordance improved from 55.3% to 76.9%, and referrals to the specialty ME/CFS clinic increased." "This suggests that publication of a clinical care algorithm on a widely accessible platform for the institution may assist in improving referring provider recognition of ME/CFS."
Article | Thread
Long Covid research
Vascular Inflammation in Neuropsychiatric Long COVID — McAlpine et al
"We identified a novel and distinct vascular inflammatory signature in Long COVID, characterized by elevations in endothelial adhesion–related biomarkers (α-2 macroglobulin, sL-selectin), suggesting a mechanism of endothelial activation rather than residual post-acute inflammation."
Article | Thread
Cerebrovascular recovery drives restoration of neurometabolite levels after mild COVID-19 — Coe et al
"We showed that GM CVR delay was associated with tCho, tCr, and tNAA levels in the thalamic region" "Unlike CVR delay itself, the concentrations of these metabolites did not exhibit spontaneous normalization as a function of post-infection time, but rather appeared to depend on vascular recovery."
Article | Thread
Reduced cortical brain perfusion following COVID-19 infection: impact of COVID-19 severity and relation to memory performance — Palmer et al
"Gray matter perfusion also uniquely predicted pattern separation performance" "the lack of prolonged damage to the white matter provides further support that disrupted perfusion is at least one of the prominent drivers of cognitive sequelae"
Article | Thread
Association between post-COVID-19 neuropsychiatric symptoms and persistent glial activation in the limbic system: a TSPO PET study — Tuomaala et al
"We found no evidence of increased TSPO availability or elevated serum biomarkers indicative of CNS damage in LC patients experiencing psychiatric and cognitive symptoms on average 17 months post-infection." "These findings suggest that persistent LC symptoms are unlikely to be driven by ongoing elevated neuroinflammation."
Article | Thread
Decreased functional connectivity in post-COVID syndrome patients with high neuroinflammatory activity — Visser et al
"Our results revealed changes in thalamic somatomotor connectivity to be mainly driven by neurocognitive complaints rather than neuroinflammatory activity."
Article | Thread
Immune Dysregulation and Persistent Symptoms: Insights into T Cell Dynamics in Post-COVID among Athletes from the CoSmo-S Study — Ringleb et al
"This is the first study highlighting the re-wiring of the immune system in the recovery period up to four months after SARS-CoV-2 infection in highly trained athletes." "indexed by a rise in Th2, Th17, naïve T cells, and NK cells, a decrease in Th1 cells and no changes in Tregs"
Article | Thread
T-cell repertoire response in individuals with post-acute sequelae of COVID-19 — Montague et al
"PASC+ individuals harbored a modestly but significantly higher fraction of SARS-CoV-2-matched rare public clones than PASC− individuals, suggesting a more persistent or broader antigen stimulation in PASC+"
Preprint | Thread
Pathogenic IgG from long COVID patients with neurological sequelae triggers sensitive but not cognitive impairments upon transfer into mice — Mignolet et al
"IgG from LC patients accumulates into the peripheral nervous system but not the central nervous system" "Our results showed that mice did not experience memory impairment, anxiety-like or depressive-like behaviors, or fatigue."
Article | Thread
Current status and future perspectives on the mechanistic and pathophysiological understanding of long COVID — Faghy et al
Review. "Although research has advanced considerably, critical gaps remain in identifying definitive diagnostic biomarkers, fully understanding disease mechanisms, and developing effective treatments."
Article | Thread
Regulatory Cycles of Orexin and Glucagon-Like Peptide-1 in Post-Viral Syndromes — Ruhrländer et al
Review/hypothesis paper. "OX dysregulation exhibits striking phenotypic overlap with PASC symptomatology, including fatigue, sleep disturbances, cognitive dysfunction, and abnormalities in glucose metabolism." "While mechanistic plausibility is strong, clinical validation remains limited, highlighting the need for targeted investigations."
Article | Thread
............
S4ME social media: Forum, Mastodon, Bluesky
News, advocacy and articles
Medscape Biological Evidence May Reshape Long-COVID Diagnosis and Care
About a summary of current evidence provided by Christian Gogoll, MD and Carmen Scheibenbogen, MD at the 132nd Congress of the German Society for Internal Medicine in Germany.
Article l Thread
#MEAction Mayo Algorithm’s Effect on ME/CFS Care
A new research paper has been published which evaluates the "care process algorithm for ME/CFS" added to the AskMayoExpert tool. This article also discusses other collaborative work that #MEAction has done with the Mayo Clinic.
Article | Thread
#MEAction $15K Matching Grant for Emergency Department Project
#MEAction received a $15,000 anonymous matching grant to fund their project to improve how people with ME/CFS and Long Covid are treated in emergency care settings.
Article | Thread
Bateman Horne Center has published their spring newsletter (May 2026).
Newsletter (PDF) | Thread
...........
Fundraising
Trial By Error Reporting on ME, ME/CFS, Long COVID, & so on...
Final week of the fundraising.
David Tuller is crowdfunding for the final time to continue his position and important work until he plans to retire from Berkeley University at the end of this year. The goal is to raise $ 75,000 by 8th May.
Crowdfunding l Thread
............
Coming events
Bateman Horne Center Free Online Support Group
Tuesday, May 5, 1 - 2 pm MDT
Topic: What’s the Meaning of All of This? Creating Purpose Out of the Illness Experience
Advance registration required, registration link shows time in your time zone.
Registration | Thread
Bateman Horne Center "Coffee" with a Clinician
Wednesday, May 13, 10 am MDT (9 am PT / 11 am CT / 12 pm ET)
Topic: Post-Exertional Malaise, Part 3
Free to attend, optional $5 donation.
Registration | Thread
...........
Research news and commentary
Australia Call for patient volunteers in Melbourne
La Trobe University study on platelet microRNAs in women. "We need ~25 more women with LC and ~5 more women with ME/CFS in Victoria".
Contact Enrolment | Thread
USA - NIH RECOVER R3 Seminar Recap: Impact of Long COVID on neurocognitive function
An update from the NIH about the April 14 seminar. A recording of the seminar is included.
Article | Video | Thread
Solve ME Systematic Underfunding of Long Covid, ME/CFS, and Other Debilitating Diseases That Disproportionately Affect Women
A "Science Spotlight" article that discusses Dr. Bonuck's recent paper on Long COVID disability burden in the US.
Article | Thread
Solve ME has posted a recording from their April 28 webinar (“The Discovery of Target Antigens for Dysfunctional T Cells in ME/CFS and Long COVID”) on their YouTube channel.
Video | Thread
..........
Research
ME/CFS research
Cardiopulmonary Exercise Testing Reveals Functional Limitations and Work Disability in Severe Post-COVID-19 and ME/CFS Patients — Tomaskovic et al
"Together, these findings suggest that functional limitations in this cohort are primarily driven by suboptimal oxygen uptake efficiency rather than central cardiac or pulmonary pathology."
Article | Thread
Symptom clusters in ME/CFS reflect distinct neuroimmune and autonomic pathophysiological mechanisms: a translational model — Habermann-Horstmeier and Horstmeier
"The proposed interpretations of underlying mechanisms derive from the integration of existing literature and were not directly measured in this study. The identified clusters therefore indicate mechanistic alignment rather than direct mechanistic validation."
Article | Thread
Health, labour market, and social service outcomes for people with Myalgic Encephalomyelitis / Chronic Fatigue Syndrome on a health or disability related benefit: an Aotearoa | New Zealand nationwide cross-sectional study using the integrated data infrastructure — Bowden et al
"Together, these findings highlight a population experiencing sustained health burden and economic vulnerability, and underscore the need for more systematic diagnostic capture and more equitable policy responses for people living with ME/CFS in NZ."
Article | Thread
Underuse of Pharmacologic Therapies for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Before Specialist Evaluation — Grach et al
"Our findings are also consistent with patient reports of clinicians being more likely to target mood concerns, as symptoms may often be labeled psychological before the actual diagnosis of ME/CFS is determined."
Article | Thread
Improving Diagnostic Accuracy of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Through a Point-of-Care Clinical Algorithm — Seltzer et al
"Between publication of the clinical tool and the end of the calendar year, 580 healthcare professionals accessed the tool, referral concordance improved from 55.3% to 76.9%, and referrals to the specialty ME/CFS clinic increased." "This suggests that publication of a clinical care algorithm on a widely accessible platform for the institution may assist in improving referring provider recognition of ME/CFS."
Article | Thread
Long Covid research
Vascular Inflammation in Neuropsychiatric Long COVID — McAlpine et al
"We identified a novel and distinct vascular inflammatory signature in Long COVID, characterized by elevations in endothelial adhesion–related biomarkers (α-2 macroglobulin, sL-selectin), suggesting a mechanism of endothelial activation rather than residual post-acute inflammation."
Article | Thread
Cerebrovascular recovery drives restoration of neurometabolite levels after mild COVID-19 — Coe et al
"We showed that GM CVR delay was associated with tCho, tCr, and tNAA levels in the thalamic region" "Unlike CVR delay itself, the concentrations of these metabolites did not exhibit spontaneous normalization as a function of post-infection time, but rather appeared to depend on vascular recovery."
Article | Thread
Reduced cortical brain perfusion following COVID-19 infection: impact of COVID-19 severity and relation to memory performance — Palmer et al
"Gray matter perfusion also uniquely predicted pattern separation performance" "the lack of prolonged damage to the white matter provides further support that disrupted perfusion is at least one of the prominent drivers of cognitive sequelae"
Article | Thread
Association between post-COVID-19 neuropsychiatric symptoms and persistent glial activation in the limbic system: a TSPO PET study — Tuomaala et al
"We found no evidence of increased TSPO availability or elevated serum biomarkers indicative of CNS damage in LC patients experiencing psychiatric and cognitive symptoms on average 17 months post-infection." "These findings suggest that persistent LC symptoms are unlikely to be driven by ongoing elevated neuroinflammation."
Article | Thread
Decreased functional connectivity in post-COVID syndrome patients with high neuroinflammatory activity — Visser et al
"Our results revealed changes in thalamic somatomotor connectivity to be mainly driven by neurocognitive complaints rather than neuroinflammatory activity."
Article | Thread
Immune Dysregulation and Persistent Symptoms: Insights into T Cell Dynamics in Post-COVID among Athletes from the CoSmo-S Study — Ringleb et al
"This is the first study highlighting the re-wiring of the immune system in the recovery period up to four months after SARS-CoV-2 infection in highly trained athletes." "indexed by a rise in Th2, Th17, naïve T cells, and NK cells, a decrease in Th1 cells and no changes in Tregs"
Article | Thread
T-cell repertoire response in individuals with post-acute sequelae of COVID-19 — Montague et al
"PASC+ individuals harbored a modestly but significantly higher fraction of SARS-CoV-2-matched rare public clones than PASC− individuals, suggesting a more persistent or broader antigen stimulation in PASC+"
Preprint | Thread
Pathogenic IgG from long COVID patients with neurological sequelae triggers sensitive but not cognitive impairments upon transfer into mice — Mignolet et al
"IgG from LC patients accumulates into the peripheral nervous system but not the central nervous system" "Our results showed that mice did not experience memory impairment, anxiety-like or depressive-like behaviors, or fatigue."
Article | Thread
Current status and future perspectives on the mechanistic and pathophysiological understanding of long COVID — Faghy et al
Review. "Although research has advanced considerably, critical gaps remain in identifying definitive diagnostic biomarkers, fully understanding disease mechanisms, and developing effective treatments."
Article | Thread
Regulatory Cycles of Orexin and Glucagon-Like Peptide-1 in Post-Viral Syndromes — Ruhrländer et al
Review/hypothesis paper. "OX dysregulation exhibits striking phenotypic overlap with PASC symptomatology, including fatigue, sleep disturbances, cognitive dysfunction, and abnormalities in glucose metabolism." "While mechanistic plausibility is strong, clinical validation remains limited, highlighting the need for targeted investigations."
Article | Thread
............
S4ME social media: Forum, Mastodon, Bluesky