Noninvasive wearable electroactive pharmaceutical monitoring for personalized therapeutics, July 2020, Lin et al (+ Ronald Davis)

wigglethemouse · Aug 1, 2020

I am included this paper as Ron Davis is one on the authors and he has talked about this type of technology in his ME/CFS talks.

This is a sweat or saliva sampling system using a custom smart watch to measure drug concentration - in this case acetaminophen (Tylenol). It is a colllaboration between Stanford and UCLA.

Published in PNAS

Significance
To achieve the mission of personalized medicine, centering on delivering the right drug to the right patient at the right dose, therapeutic drug monitoring solutions are necessary.

By devising a surface engineering strategy, we created a voltammetric sensing interface, featuring an “undistorted potential window,” within which the target electroactive drug’s voltammetric response is dominant and interference is eliminated, rendering reliable target quantification in noninvasively retrievable biofluids (sweat and saliva).

Leveraging this sensing interface, a fully integrated, wearable solution was constructed to seamlessly render drug readouts with minute-level temporal resolution.

To inform its clinical utility, the solution was utilized to demonstrate noninvasive pharmacokinetic monitoring of a pharmaceutical (here, acetaminophen, a widely used analgesic and antipyretic) in a wearable format.
Click to expand...

Abstract
To achieve the mission of personalized medicine, centering on delivering the right drug to the right patient at the right dose, therapeutic drug monitoring solutions are necessary.

In that regard, wearable biosensing technologies, capable of tracking drug pharmacokinetics in noninvasively retrievable biofluids (e.g., sweat), play a critical role, because they can be deployed at a large scale to monitor the individuals’ drug transcourse profiles (semi)continuously and longitudinally.

To this end, voltammetry-based sensing modalities are suitable, as in principle they can detect and quantify electroactive drugs on the basis of the target’s redox signature.

However, the target’s redox signature in complex biofluid matrices can be confounded by the immediate biofouling effects and distorted/buried by the interfering voltammetric responses of endogenous electroactive species.

Here, we devise a wearable voltammetric sensor development strategy—centering on engineering the molecule–surface interactions—to simultaneously mitigate biofouling and create an “undistorted potential window” within which the target drug’s voltammetric response is dominant and interference is eliminated.

To inform its clinical utility, our strategy was adopted to track the temporal profile of circulating acetaminophen (a widely used analgesic and antipyretic) in saliva and sweat, using a surface-modified boron-doped diamond sensing interface (cross-validated with laboratory-based assays, R2 ~ 0.94).

Through integration of the engineered sensing interface within a custom-developed smartwatch, and augmentation with a dedicated analytical framework (for redox peak extraction), we realized a wearable solution to seamlessly render drug readouts with minute-level temporal resolution.

Leveraging this solution, we demonstrated the pharmacokinetic correlation and significance of sweat readings.
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PNAS link : https://www.pnas.org/content/early/2020/07/22/2009979117
Sci-hub : https://sci-hub.se/https://www.pnas.org/content/early/2020/07/22/2009979117

Midnattsol · Aug 1, 2020

I hope we get somerhing like this that can measure more than just glucose and lactate in the future, I'm sure it could provide interesting data: https://www.iamsweati.com/home

Trish · Aug 1, 2020

wigglethemouse said: ↑

This is a sweat or saliva sampling system using a custom smart watch to measure drug concentration - in this case acetaminophen (Tylenol).
Click to expand...

And known in the UK as paracetamol.

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Noninvasive wearable electroactive pharmaceutical monitoring for personalized therapeutics, July 2020, Lin et al (+ Ronald Davis)

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