Periodic Paralysis Across the Life Course: Age-related Phenotype

Interesting study that explores RYR1 gene variations and their import to things like muscle weakness and ATP and mitochondrial function, and how these change with age in healthy individuals vs those with channelopathies. RYR1 variations have been tied into ME/CFS before.

This study parses down on RYR1 variations and compares different age groups of healthy individuals and the pathophysiology of major categories of periodic paralysis. It highlights ionic homeostasis vs gradual degradation and the implications to muscle weakness and energy depletion.

I thought there might be some insight into potential mechanisms involved in ME/CFS.

https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2024.1507485/full